DegronMD

Uniprot ID: Q8NFA0

Source protein: Ubiquitin carboxyl-terminal hydrolase 32

Source gene: USP32

Class: DEG_SPOP_SBC_1

Location: 1584:1588

E3 ligase: SPOP

DEGRON score: 0.6823

ASA_SCORE: 80.66

COIL: 0.7978

CONS_SCORE: 0.2684

DSS_SCORE: 0.4376

HELIX: 0.1734

FCONS_SCORE: 0.7681

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1585Y	TCGA-44-2668	LUAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.6214
p.D1585Y	DO25232	LUAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.6214
p.E1591K	TCGA-AO-A03M	BRCA	TCGA	ADTSS	DEG_SPOP_SBC_1	0.25
p.E1591K	DO48413	BLCA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.25
p.E1591K	DO2216	BRCA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.25
p.T1578I	DO229052	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1667
p.M1589V	ACH-000937	Leukemia	CCLE	ADTSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23759	Paired box protein Pax-7	DEG_SPOP_SBC_1	346:350	ADTSS	SPOP	0.5936	More...
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_SPOP_SBC_1	1386:1390	ADTSS	SPOP	0.8488	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	867:871	ADTSS	SPOP	0.9941	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	227:231	ADTSS	SPOP	0.9912	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	771:775	ADTSS	SPOP	0.8619	More...
Q6UVM3	Potassium channel subfamily T member 2	DEG_SPOP_SBC_1	636:640	ADTSS	SPOP	0.9248	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	604:608	ADTSS	SPOP	0.9979	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_SPOP_SBC_1	1584:1588	ADTSS	SPOP	0.6823	More...
Q96KM6	Zinc finger protein 512B	DEG_SPOP_SBC_1	382:386	ADTSS	SPOP	0.9081	More...
Q99708	DNA endonuclease RBBP8	DEG_SPOP_SBC_1	14:18	ADTSS	SPOP	0.8958	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	2460:2464	ADTSS	SPOP	0.8672	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_SPOP_SBC_1	756:760	ADTSS	SPOP	0.982	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1113:1117	ADTSS	SPOP	0.995	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	430:434	ADTSS	SPOP	0.8521	More...
Q6ZMY6	WD repeat-containing protein 88	DEG_SPOP_SBC_1	449:453	ADTSS	SPOP	0.5826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons