DegronMD - P23759(PAX7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A342V	TCGA-DU-6392	LGG	TCGA	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.A342V	DO22237	LGG	ICGC	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.R355H	TCGA-SL-A6JA	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.R355H	DO219787	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.D434N	TCGA-W3-A825	SKCM	TCGA	PPTY	ITCH	444:447	Mutation rewiring degron network	0.0556
p.D434N	DO51272	SKCM	ICGC	PPTY	ITCH	444:447	Mutation rewiring degron network	0.0556
p.L339R	DO233203	GACA	ICGC	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1389
p.S435G	DO233766	GACA	ICGC	PPTY	ITCH	444:447	Mutation rewiring degron network	0.0833
p.A351S	DO228948	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.3056
p.S435N	DO222875	MELA	ICGC	PPTY	ITCH	444:447	Mutation rewiring degron network	0.0833
p.Q440K	DO34736	PACA	ICGC	PPTY	ITCH	444:447	Mutation rewiring degron network	0.2222
p.V454M	SIDM02059	Colorectal Carcinoma	GDSC	PPTY	ITCH	444:447	Mutation rewiring degron network	0.1389
p.A354G	SIDM00965	Small Cell Lung Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.A354G	ACH-000800	Lung Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.A354G	NCI-H446	lung	COSMIC	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.V457L	SIDM00576	Acute Myeloid Leukemia	GDSC	PPTY	ITCH	444:447	Mutation rewiring degron network	0.0556
p.V457L	ACH-002290	Leukemia	CCLE	PPTY	ITCH	444:447	Mutation rewiring degron network	0.0556
p.V457L	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	444:447	Mutation rewiring degron network	0.0556
p.Y352C	ACH-001099	Rhabdoid	CCLE	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2778
p.A352G	NCI-H446	lung	COSMIC	ADTSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2778
p.V455L	NKM-1	haematopoietic and lymphoid tissue	COSMIC	PPTY	ITCH	444:447	Mutation rewiring degron network	0.1111

Kaplan plot for PAX7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PAX7

UniProt ID: P23759

Entrez ID: 5081

Protein name: Paired box protein Pax-7 (HuP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PAX7 in