DegronMD - Q6UVM3(KCNT2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D645N	TCGA-A5-A0G2	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1944
p.D645N	DO41235	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1944
p.D645N	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1944
p.D645N	ACH-000656	Lymphoma	CCLE	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1944
p.D645N	SU-DHL-8	NS	COSMIC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1944
p.S640L	TCGA-AJ-A5DW	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7667
p.S640L	TCGA-D8-A1J8	BRCA	TCGA	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7667
p.S640L	DO1269	BRCA	ICGC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7667
p.S640L	DO50075	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7667
p.S640L	SIDM00648	Small Cell Lung Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7667
p.S640L	SIDM00092	Ovarian Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7667
p.S640L	ACH-000617	Ovarian Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7667
p.S640L	ACH-002169	Lung Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7667
p.T638K	TCGA-CM-6674	COAD	TCGA	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7306
p.T638K	DO10092	COAD	ICGC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation altering degron motif	0.7306
p.I641T	TCGA-CV-7252	HNSC	TCGA	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.3056
p.I641T	DO14176	HNSC	ICGC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.3056
p.D645Y	TCGA-KQ-A41N	BLCA	TCGA	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1944
p.D645Y	DO223588	BLCA	ICGC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1944
p.V632I	TCGA-NC-A5HT	LUSC	TCGA	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.2222
p.V632I	DO219205	LUSC	ICGC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.2222
p.R626K	TCGA-WE-A8K6	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.0556
p.R626K	DO51283	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.0556
p.I629N	SIDM00007	Other Solid Cancers	GDSC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1389
p.I629N	ACH-001550	Skin Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1389
p.I629N	MCC13	skin	COSMIC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1389
p.L646F	SIDM00149	Melanoma	GDSC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1667
p.L646F	ACH-000750	Skin Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1667
p.L646F	LOXIMVI	skin	COSMIC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.1667
p.V632F	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.2222
p.V632F	ACH-000875	Lung Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.2222
p.V632F	NCI-H2347	lung	COSMIC	ADTSS	DEG_SPOP_SBC_1	636:640	Mutation rewiring degron network	0.2222

Kaplan plot for KCNT2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNT2

UniProt ID: Q6UVM3

Entrez ID: 343450

Protein name: Potassium channel subfamily T member 2 (Sequence like an intermediate conductance potassium channel subunit) (Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KCNT2 in