DegronMD

Uniprot ID: Q6UVM3

Source protein: Potassium channel subfamily T member 2

Source gene: KCNT2

Class: DEG_SPOP_SBC_1

Location: 636:640

E3 ligase: SPOP

DEGRON score: 0.9248

ASA_SCORE: 67.74

COIL: 0.7744

CONS_SCORE: 0.3843

DSS_SCORE: 0.4787

HELIX: 0.1474

FCONS_SCORE: 0.9204

RIG_SCORE: 0.7462

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D645N	TCGA-A5-A0G2	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1944
p.D645N	DO41235	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1944
p.D645N	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.1944
p.D645N	ACH-000656	Lymphoma	CCLE	ADTSS	DEG_SPOP_SBC_1	0.1944
p.D645N	SU-DHL-8	NS	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.1944
p.S640L	TCGA-AJ-A5DW	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.7667
p.S640L	TCGA-D8-A1J8	BRCA	TCGA	ADTSS	DEG_SPOP_SBC_1	0.7667
p.S640L	DO1269	BRCA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.7667
p.S640L	DO50075	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.7667
p.S640L	SIDM00648	Small Cell Lung Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.7667
p.S640L	SIDM00092	Ovarian Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.7667
p.S640L	ACH-000617	Ovarian Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.7667
p.S640L	ACH-002169	Lung Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.7667
p.T638K	TCGA-CM-6674	COAD	TCGA	ADTSS	DEG_SPOP_SBC_1	0.7306
p.T638K	DO10092	COAD	ICGC	ADTSS	DEG_SPOP_SBC_1	0.7306
p.I641T	TCGA-CV-7252	HNSC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.3056
p.I641T	DO14176	HNSC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.3056
p.D645Y	TCGA-KQ-A41N	BLCA	TCGA	ADTSS	DEG_SPOP_SBC_1	0.1944
p.D645Y	DO223588	BLCA	ICGC	ADTSS	DEG_SPOP_SBC_1	0.1944
p.V632I	TCGA-NC-A5HT	LUSC	TCGA	ADTSS	DEG_SPOP_SBC_1	0.2222
p.V632I	DO219205	LUSC	ICGC	ADTSS	DEG_SPOP_SBC_1	0.2222
p.R626K	TCGA-WE-A8K6	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	0.0556
p.R626K	DO51283	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	0.0556
p.I629N	SIDM00007	Other Solid Cancers	GDSC	ADTSS	DEG_SPOP_SBC_1	0.1389
p.I629N	ACH-001550	Skin Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.1389
p.I629N	MCC13	skin	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.1389
p.L646F	SIDM00149	Melanoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.1667
p.L646F	ACH-000750	Skin Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.1667
p.L646F	LOXIMVI	skin	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.1667
p.V632F	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	ADTSS	DEG_SPOP_SBC_1	0.2222
p.V632F	ACH-000875	Lung Cancer	CCLE	ADTSS	DEG_SPOP_SBC_1	0.2222
p.V632F	NCI-H2347	lung	COSMIC	ADTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23759	Paired box protein Pax-7	DEG_SPOP_SBC_1	346:350	ADTSS	SPOP	0.5936	More...
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_SPOP_SBC_1	1386:1390	ADTSS	SPOP	0.8488	More...
P49750	YLP motif-containing protein 1	DEG_SPOP_SBC_1	867:871	ADTSS	SPOP	0.9941	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	227:231	ADTSS	SPOP	0.9912	More...
Q6T4R5	Nance-Horan syndrome protein	DEG_SPOP_SBC_1	771:775	ADTSS	SPOP	0.8619	More...
Q6UVM3	Potassium channel subfamily T member 2	DEG_SPOP_SBC_1	636:640	ADTSS	SPOP	0.9248	More...
Q7Z417	Nuclear fragile X mental retardation-interacting protein 2	DEG_SPOP_SBC_1	604:608	ADTSS	SPOP	0.9979	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_SPOP_SBC_1	1584:1588	ADTSS	SPOP	0.6823	More...
Q96KM6	Zinc finger protein 512B	DEG_SPOP_SBC_1	382:386	ADTSS	SPOP	0.9081	More...
Q99708	DNA endonuclease RBBP8	DEG_SPOP_SBC_1	14:18	ADTSS	SPOP	0.8958	More...
Q9BYW2	Histone-lysine N-methyltransferase SETD2	DEG_SPOP_SBC_1	2460:2464	ADTSS	SPOP	0.8672	More...
Q9H2G2	STE20-like serine/threonine-protein kinase	DEG_SPOP_SBC_1	756:760	ADTSS	SPOP	0.982	More...
Q9Y3R5	Protein dopey-2	DEG_SPOP_SBC_1	1113:1117	ADTSS	SPOP	0.995	More...
Q9Y613	FH1/FH2 domain-containing protein 1	DEG_SPOP_SBC_1	430:434	ADTSS	SPOP	0.8521	More...
Q6ZMY6	WD repeat-containing protein 88	DEG_SPOP_SBC_1	449:453	ADTSS	SPOP	0.5826	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADTSS

Degron related mutations and impact score

Drug responses associated with KCNT2 mutations

All proteins holding degron of ADTSS