DegronMD - P35125(USP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1394E	TCGA-A5-A0G1	UCEC	TCGA	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.2222
p.D1394E	DO42472	UCEC	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.2222
p.A1233D	TCGA-AA-3984	COAD	TCGA	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation rewiring degron network	0.3056
p.A1233D	DO9002	COAD	ICGC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation rewiring degron network	0.3056
p.A1227V	TCGA-AG-A002	READ	TCGA	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation rewiring degron network	0.3056
p.K1223N	TCGA-AP-A056	UCEC	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation substituting flanking lysine	0.1667
p.K1223N	TCGA-AP-A056	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation substituting flanking lysine	0.3056
p.K1223N	TCGA-AX-A05Z	UCEC	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation substituting flanking lysine	0.1667
p.K1223N	TCGA-AX-A05Z	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation substituting flanking lysine	0.3056
p.K1223N	DO40884	UCEC	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation substituting flanking lysine	0.1667
p.K1223N	DO40884	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation substituting flanking lysine	0.3056
p.K1223N	DO43971	UCEC	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation substituting flanking lysine	0.1667
p.K1223N	DO43971	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation substituting flanking lysine	0.3056
p.G900R	TCGA-BF-A1PZ	SKCM	TCGA	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation altering degron motif	0.6457
p.G900R	DO50279	SKCM	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation altering degron motif	0.6457
p.D1398N	TCGA-BF-A5EQ	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.1111
p.D1398N	DO219452	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.1111
p.G1201W	TCGA-BR-6456	STAD	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.2222
p.G1201W	DO38655	STAD	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.2222
p.S1195I	TCGA-BS-A0UF	UCEC	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.0556
p.S1195I	DO41488	UCEC	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.0556
p.G1232E	TCGA-DA-A3F8	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation altering degron motif	0.6087
p.G1232E	DO37418	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation altering degron motif	0.6087
p.T911I	TCGA-DA-A95X	SKCM	TCGA	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.0833
p.T911I	DO219480	SKCM	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.0833
p.R1208W	TCGA-EE-A29D	SKCM	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.7523
p.R1208W	TCGA-FR-A726	SKCM	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.7523
p.R1208W	DO48665	SKCM	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.7523
p.R1208W	DO38123	SKCM	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation altering degron motif	0.7523
p.R895C	TCGA-ER-A19F	SKCM	TCGA	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation altering degron motif	0.8301
p.R895C	DO37679	SKCM	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation altering degron motif	0.8301
p.R895C	SIDM00425	Ovarian Carcinoma	GDSC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation altering degron motif	0.8301
p.R895C	SIDM00986	Head and Neck Carcinoma	GDSC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation altering degron motif	0.8301
p.R895C	BHY	upper aerodigestive tract	COSMIC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation altering degron motif	0.8301
p.R895C	OVTOKO	ovary	COSMIC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation altering degron motif	0.8301
p.E1400K	TCGA-ER-A19Q	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.0556
p.E1400K	DO228331	BRCA	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.0556
p.E1400K	DO218863	SKCA	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.0556
p.E1400K	DO47497	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.0556
p.D1392N	TCGA-GN-A8LK	SKCM	TCGA	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.2778
p.D1392N	DO51259	SKCM	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.2778
p.R1198L	TCGA-IN-A6RL	STAD	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.1389
p.R1198L	DO51738	STAD	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.1389
p.P1378Q	TCGA-L9-A7SV	LUAD	TCGA	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.1111
p.P1378Q	DO49875	LUAD	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation rewiring degron network	0.1111
p.R912Q	DO229016	COCA	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.0556
p.R912Q	DO229003	COCA	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.0556
p.R912Q	DO230993	LUSC	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.0556
p.R912Q	DO230990	LUSC	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.0556
p.R912Q	DO231049	LUSC	ICGC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.0556
p.S1395F	DO229030	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation blocking phosphorylation signal	0.6389
p.T1391M	DO229053	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation blocking phosphorylation signal	0.75
p.S1389N	DO23466	LINC	ICGC	ADTSS	DEG_SPOP_SBC_1	1386:1390	Mutation altering degron motif	0.7069
p.C1237R	DO229259	THCA	ICGC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation rewiring degron network	0.1944
p.L1239Q	DO229211	THCA	ICGC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation rewiring degron network	0.1389
p.E1230D	DO229221	THCA	ICGC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation altering degron motif	0.6758
p.E1230D	SIDM00193	Colorectal Carcinoma	GDSC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation altering degron motif	0.6758
p.E1230D	ACH-000991	Colon/Colorectal Cancer	CCLE	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation altering degron motif	0.6758
p.E1230D	SNU-81	large intestine	COSMIC	SKENG	DEG_APCC_KENBOX_2	1228:1232	Mutation altering degron motif	0.6758
p.T1199I	SIDM01265	Plasma Cell Myeloma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation blocking phosphorylation signal	0.6111
p.T1199I	SIDM01245	T-Lymphoblastic Leukemia	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation blocking phosphorylation signal	0.6111
p.T1199I	SIDM00099	Mesothelioma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation blocking phosphorylation signal	0.6111
p.T1199I	SIDM00203	Ewing's Sarcoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation blocking phosphorylation signal	0.6111
p.T1199I	SIDM00094	Kidney Carcinoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation blocking phosphorylation signal	0.6111
p.T1199I	SIDM00991	T-Lymphoblastic Leukemia	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation blocking phosphorylation signal	0.6111
p.R1202G	SIDM00774	Breast Carcinoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.25
p.R1202G	ACH-000691	Breast Cancer	CCLE	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.25
p.R1202G	HCC2157	breast	COSMIC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.25
p.R1198Q	SIDM01105	Melanoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.1389
p.R1198Q	ACH-000423	Skin Cancer	CCLE	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.1389
p.R1198Q	SK-MEL-3	skin	COSMIC	GRLRLPQIG	DEG_APCC_DBOX_1	1205:1213	Mutation rewiring degron network	0.1389
p.L886P	SIDM01608	Endometrial Carcinoma	GDSC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.1111
p.L886P	ACH-000990	Endometrial/Uterine Cancer	CCLE	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.1111
p.V909L	SIDM01766	Chondrosarcoma	GDSC	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.1389
p.V909L	ACH-000418	Bone Cancer	CCLE	NRPSLFGMP	DEG_APCC_DBOX_1	894:902	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP6

UniProt ID: P35125

Entrez ID: 9098

Protein name: Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP6 in