DegronMD

Uniprot ID: P35125

Source protein: Ubiquitin carboxyl-terminal hydrolase 6

Source gene: USP6

Class: DEG_APCC_KENBOX_2

Location: 1228:1232

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8615

ASA_SCORE: 85.84

COIL: 0.7262

CONS_SCORE: 0.281

DSS_SCORE: 0.5498

HELIX: 0.2188

FCONS_SCORE: 1.0358

RIG_SCORE: 0.6286

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1233D	TCGA-AA-3984	COAD	TCGA	SKENG	DEG_APCC_KENBOX_2	0.3056
p.A1233D	DO9002	COAD	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.A1227V	TCGA-AG-A002	READ	TCGA	SKENG	DEG_APCC_KENBOX_2	0.3056
p.K1223N	TCGA-AP-A056	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.3056
p.K1223N	TCGA-AX-A05Z	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.3056
p.K1223N	DO40884	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.K1223N	DO43971	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.G1232E	TCGA-DA-A3F8	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.6087
p.G1232E	DO37418	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6087
p.C1237R	DO229259	THCA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.1944
p.L1239Q	DO229211	THCA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.1389
p.E1230D	DO229221	THCA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6758
p.E1230D	SIDM00193	Colorectal Carcinoma	GDSC	SKENG	DEG_APCC_KENBOX_2	0.6758
p.E1230D	ACH-000991	Colon/Colorectal Cancer	CCLE	SKENG	DEG_APCC_KENBOX_2	0.6758
p.E1230D	SNU-81	large_intestine	COSMIC	SKENG	DEG_APCC_KENBOX_2	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_KENBOX_2	1228:1232	SKENG	APC,CDC20,FZR1	0.8615	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	125:129	SKENG	APC,CDC20,FZR1	0.9622	More...
Q12908	Ileal sodium/bile acid cotransporter	DEG_APCC_KENBOX_2	325:329	SKENG	APC,CDC20,FZR1	0.6472	More...
Q13596	Sorting nexin-1	DEG_APCC_KENBOX_2	72:76	SKENG	APC,CDC20,FZR1	0.924	More...
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_APCC_KENBOX_2	1143:1147	SKENG	APC,CDC20,FZR1	0.9857	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1430:1434	SKENG	APC,CDC20,FZR1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons