DegronMD - Q12908(SLC10A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E324Q	TCGA-22-5479	LUSC	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.E324Q	DO27287	LUSC	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.E324D	TCGA-62-A46P	LUAD	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.E324D	DO25767	LUAD	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.E327G	TCGA-A5-A1OF	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation altering degron motif	0.7199
p.E327G	DO42568	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation altering degron motif	0.7199
p.T330M	TCGA-AP-A1DV	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.T330M	DO234250	ESAD	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.T330M	DO222521	MELA	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.T330M	DO43186	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.S335L	TCGA-BF-A1PV	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	TCGA-EB-A41A	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	TCGA-EE-A29D	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	TCGA-EE-A2A2	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	TCGA-EE-A2GU	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	DO220881	MELA	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	DO37639	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	DO37583	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	DO37429	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	DO47309	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	DO38123	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	SIDM00655	Other Solid Cancers	GDSC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	ACH-001578	Embryonal Cancer	CCLE	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.S335L	NCCIT	testis	COSMIC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation blocking phosphorylation signal	0.6111
p.E331K	TCGA-D3-A2JH	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2778
p.E331K	DO47263	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2778
p.E331K	SIDM01064	Hodgkin's Lymphoma	GDSC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2778
p.E331K	ACH-000267	Lymphoma	CCLE	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2778
p.E331K	HDLM-2	haematopoietic and lymphoid tissue	COSMIC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2778
p.K338E	TCGA-E2-A105	BRCA	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation substituting flanking lysine	0.1944
p.K338E	DO3536	BRCA	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation substituting flanking lysine	0.1944
p.K338R	TCGA-GN-A265	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation substituting flanking lysine	0.1944
p.K338R	DO37491	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation substituting flanking lysine	0.1944
p.E327Q	TCGA-Q1-A73O	CESC	TCGA	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation altering degron motif	0.6744
p.E327Q	DO51612	CESC	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation altering degron motif	0.6744
p.A339V	DO233941	GACA	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.0556
p.T330K	DO229009	LICA	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.3056
p.P323S	DO229465	SKCA	ICGC	SKENG	DEG_APCC_KENBOX_2	325:329	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC10A2

UniProt ID: Q12908

Entrez ID: 6555

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC10A2 in