DegronMD

Uniprot ID: Q12908

Source protein: Ileal sodium/bile acid cotransporter

Source gene: SLC10A2

Class: DEG_APCC_KENBOX_2

Location: 325:329

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6472

ASA_SCORE: 100.42

COIL: 0.81

CONS_SCORE: 0.257

DSS_SCORE: 0.5823

HELIX: 0.1696

FCONS_SCORE: 1.0564

RIG_SCORE: 0.6323

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E324Q	TCGA-22-5479	LUSC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.3056
p.E324Q	DO27287	LUSC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.E324D	TCGA-62-A46P	LUAD	TCGA	SKENG	DEG_APCC_KENBOX_2	0.3056
p.E324D	DO25767	LUAD	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.E327G	TCGA-A5-A1OF	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.7199
p.E327G	DO42568	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.7199
p.T330M	TCGA-AP-A1DV	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.3056
p.T330M	DO234250	ESAD	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.T330M	DO222521	MELA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.T330M	DO43186	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.S335L	TCGA-BF-A1PV	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	TCGA-EB-A41A	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	TCGA-EE-A29D	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	TCGA-EE-A2A2	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	TCGA-EE-A2GU	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	DO220881	MELA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	DO37639	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	DO37583	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	DO37429	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	DO47309	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	DO38123	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	SIDM00655	Other Solid Cancers	GDSC	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	ACH-001578	Embryonal Cancer	CCLE	SKENG	DEG_APCC_KENBOX_2	0.6111
p.S335L	NCCIT	testis	COSMIC	SKENG	DEG_APCC_KENBOX_2	0.6111
p.E331K	TCGA-D3-A2JH	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.2778
p.E331K	DO47263	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.2778
p.E331K	SIDM01064	Hodgkin's Lymphoma	GDSC	SKENG	DEG_APCC_KENBOX_2	0.2778
p.E331K	ACH-000267	Lymphoma	CCLE	SKENG	DEG_APCC_KENBOX_2	0.2778
p.E331K	HDLM-2	haematopoietic_and_lymphoid_tissue	COSMIC	SKENG	DEG_APCC_KENBOX_2	0.2778
p.K338E	TCGA-E2-A105	BRCA	TCGA	SKENG	DEG_APCC_KENBOX_2	0.1944
p.K338E	DO3536	BRCA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.1944
p.K338R	TCGA-GN-A265	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.1944
p.K338R	DO37491	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.1944
p.E327Q	TCGA-Q1-A73O	CESC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.6744
p.E327Q	DO51612	CESC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6744
p.A339V	DO233941	GACA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.0556
p.T330K	DO229009	LICA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.P323S	DO229465	SKCA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_KENBOX_2	1228:1232	SKENG	APC,CDC20,FZR1	0.8615	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	125:129	SKENG	APC,CDC20,FZR1	0.9622	More...
Q12908	Ileal sodium/bile acid cotransporter	DEG_APCC_KENBOX_2	325:329	SKENG	APC,CDC20,FZR1	0.6472	More...
Q13596	Sorting nexin-1	DEG_APCC_KENBOX_2	72:76	SKENG	APC,CDC20,FZR1	0.924	More...
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_APCC_KENBOX_2	1143:1147	SKENG	APC,CDC20,FZR1	0.9857	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1430:1434	SKENG	APC,CDC20,FZR1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKENG

Degron related mutations and impact score

Drug responses associated with SLC10A2 mutations

All proteins holding degron of SKENG