DegronMD - Q8NFA0(USP32)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1585Y	TCGA-44-2668	LUAD	TCGA	ADTSS	DEG_SPOP_SBC_1	1584:1588	Mutation altering degron motif	0.6214
p.D1585Y	DO25232	LUAD	ICGC	ADTSS	DEG_SPOP_SBC_1	1584:1588	Mutation altering degron motif	0.6214
p.E1440Q	TCGA-85-A4JC	LUSC	TCGA	SKENG	DEG_APCC_KENBOX_2	1430:1434	Mutation rewiring degron network	0.1667
p.E1440Q	DO45429	LUSC	ICGC	SKENG	DEG_APCC_KENBOX_2	1430:1434	Mutation rewiring degron network	0.1667
p.E1425D	TCGA-85-A4JC	LUSC	TCGA	SKENL	DEG_APCC_KENBOX_2	1423:1427	Mutation altering degron motif	0.6758
p.E1425D	DO45429	LUSC	ICGC	SKENL	DEG_APCC_KENBOX_2	1423:1427	Mutation altering degron motif	0.6758
p.E1591K	TCGA-AO-A03M	BRCA	TCGA	ADTSS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.25
p.E1591K	DO48413	BLCA	ICGC	ADTSS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.25
p.E1591K	DO2216	BRCA	ICGC	ADTSS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.25
p.S1405C	TCGA-AY-6196	COAD	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation rewiring degron network	0.2778
p.S1405C	DO10300	COAD	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation rewiring degron network	0.2778
p.K1417E	TCGA-CG-4437	STAD	TCGA	SKENL	DEG_APCC_KENBOX_2	1423:1427	Mutation substituting flanking lysine	0.2778
p.K1417E	DO38467	STAD	ICGC	SKENL	DEG_APCC_KENBOX_2	1423:1427	Mutation substituting flanking lysine	0.2778
p.N1433Y	TCGA-CR-7370	HNSC	TCGA	SKENG	DEG_APCC_KENBOX_2	1430:1434	Mutation altering degron motif	0.7059
p.N1433Y	DO14426	HNSC	ICGC	SKENG	DEG_APCC_KENBOX_2	1430:1434	Mutation altering degron motif	0.7059
p.G1407W	DO225337	BRCA	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation altering degron motif	0.6714
p.G1407W	DO233688	GACA	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation altering degron motif	0.6714
p.T1578I	DO229052	LICA	ICGC	ADTSS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.1667
p.R1400Q	DO222837	MELA	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation rewiring degron network	0.1389
p.A1429V	SIDM01129	Small Cell Lung Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	1423:1427	Mutation rewiring degron network	0.2778
p.A1429V	SIDM01129	Small Cell Lung Carcinoma	GDSC	SKENG	DEG_APCC_KENBOX_2	1430:1434	Mutation rewiring degron network	0.3056
p.A1429V	ACH-000816	Lung Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	1423:1427	Mutation rewiring degron network	0.2778
p.A1429V	ACH-000816	Lung Cancer	CCLE	SKENG	DEG_APCC_KENBOX_2	1430:1434	Mutation rewiring degron network	0.3056
p.A1429V	NCI-H524	lung	COSMIC	SKENL	DEG_APCC_KENBOX_2	1423:1427	Mutation rewiring degron network	0.2778
p.A1429V	NCI-H524	lung	COSMIC	SKENG	DEG_APCC_KENBOX_2	1430:1434	Mutation rewiring degron network	0.3056
p.R1410L	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation altering degron motif	0.7316
p.R1410L	ACH-000785	Lung Cancer	CCLE	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation altering degron motif	0.7316
p.R1410L	NCI-H2126	lung	COSMIC	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation altering degron motif	0.7316
p.G1415A	SIDM00699	Small Cell Lung Carcinoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation altering degron motif	0.6429
p.G1415A	ACH-001138	Lung Cancer	CCLE	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation altering degron motif	0.6429
p.G1415A	NCI-H2141	lung	COSMIC	GRLRLPQIG	DEG_APCC_DBOX_1	1407:1415	Mutation altering degron motif	0.6429
p.M1589V	ACH-000937	Leukemia	CCLE	ADTSS	DEG_SPOP_SBC_1	1584:1588	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP32

UniProt ID: Q8NFA0

Entrez ID: 84669

Protein name: Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP32 in