DegronMD

Uniprot ID: Q8NFA0

Source protein: Ubiquitin carboxyl-terminal hydrolase 32

Source gene: USP32

Class: DEG_APCC_DBOX_1

Location: 1407:1415

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6457

ASA_SCORE: 90.0556

COIL: 0.7711

CONS_SCORE: 0.2508

DSS_SCORE: 0.7018

HELIX: 0.0718

FCONS_SCORE: 0.9771

RIG_SCORE: 0.6739

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1405C	TCGA-AY-6196	COAD	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	0.2778
p.S1405C	DO10300	COAD	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.2778
p.G1407W	DO225337	BRCA	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6714
p.G1407W	DO233688	GACA	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6714
p.R1400Q	DO222837	MELA	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.1389
p.R1410L	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.7316
p.R1410L	ACH-000785	Lung Cancer	CCLE	GRLRLPQIG	DEG_APCC_DBOX_1	0.7316
p.R1410L	NCI-H2126	lung	COSMIC	GRLRLPQIG	DEG_APCC_DBOX_1	0.7316
p.G1415A	SIDM00699	Small Cell Lung Carcinoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6429
p.G1415A	ACH-001138	Lung Cancer	CCLE	GRLRLPQIG	DEG_APCC_DBOX_1	0.6429
p.G1415A	NCI-H2141	lung	COSMIC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_DBOX_1	1205:1213	GRLRLPQIG	APC,CDC20,FZR1	0.6488	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_DBOX_1	1407:1415	GRLRLPQIG	APC,CDC20,FZR1	0.6457	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons