DegronMD

Uniprot ID: P35125

Source protein: Ubiquitin carboxyl-terminal hydrolase 6

Source gene: USP6

Class: DEG_APCC_DBOX_1

Location: 1205:1213

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6488

ASA_SCORE: 93.1889

COIL: 0.8178

CONS_SCORE: 0.2577

DSS_SCORE: 0.794

HELIX: 0.0424

FCONS_SCORE: 1.0124

RIG_SCORE: 0.6526

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1208W	TCGA-EE-A29D	SKCM	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	0.7523
p.R1208W	TCGA-FR-A726	SKCM	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	0.7523
p.R1208W	DO48665	SKCM	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.7523
p.R1208W	DO38123	SKCM	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.7523
p.T1199I	SIDM01265	Plasma Cell Myeloma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6111
p.T1199I	SIDM01245	T-Lymphoblastic Leukemia	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6111
p.T1199I	SIDM00099	Mesothelioma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6111
p.T1199I	SIDM00203	Ewing's Sarcoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6111
p.T1199I	SIDM00094	Kidney Carcinoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6111
p.T1199I	SIDM00991	T-Lymphoblastic Leukemia	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.6111
p.R1202G	SIDM00774	Breast Carcinoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.25
p.R1202G	ACH-000691	Breast Cancer	CCLE	GRLRLPQIG	DEG_APCC_DBOX_1	0.25
p.R1202G	HCC2157	breast	COSMIC	GRLRLPQIG	DEG_APCC_DBOX_1	0.25
p.G1201W	TCGA-BR-6456	STAD	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	0.2222
p.G1201W	DO38655	STAD	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.2222
p.K1223N	TCGA-AP-A056	UCEC	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	0.1667
p.K1223N	TCGA-AX-A05Z	UCEC	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	0.1667
p.K1223N	DO40884	UCEC	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.1667
p.K1223N	DO43971	UCEC	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.1667
p.R1198L	TCGA-IN-A6RL	STAD	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	0.1389
p.R1198L	DO51738	STAD	ICGC	GRLRLPQIG	DEG_APCC_DBOX_1	0.1389
p.R1198Q	SIDM01105	Melanoma	GDSC	GRLRLPQIG	DEG_APCC_DBOX_1	0.1389
p.R1198Q	ACH-000423	Skin Cancer	CCLE	GRLRLPQIG	DEG_APCC_DBOX_1	0.1389
p.R1198Q	SK-MEL-3	skin	COSMIC	GRLRLPQIG	DEG_APCC_DBOX_1	0.1389
p.S1195I	TCGA-BS-A0UF	UCEC	TCGA	GRLRLPQIG	DEG_APCC_DBOX_1	0.0556

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Drug responses associated with USP6 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of GRLRLPQIG

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_DBOX_1	1407:1415	GRLRLPQIG	APC,CDC20,FZR1	0.6457	More...
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_DBOX_1	1205:1213	GRLRLPQIG	APC,CDC20,FZR1	0.6488	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: GRLRLPQIG

Degron related mutations and impact score

Drug responses associated with USP6 mutations

All proteins holding degron of GRLRLPQIG