DegronMD

Uniprot ID: Q8NFA0

Source protein: Ubiquitin carboxyl-terminal hydrolase 32

Source gene: USP32

Class: DEG_APCC_KENBOX_2

Location: 1430:1434

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9942

ASA_SCORE: 88.72

COIL: 0.6768

CONS_SCORE: 0.2223

DSS_SCORE: 0.4767

HELIX: 0.2894

FCONS_SCORE: 1.1385

RIG_SCORE: 0.6509

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1440Q	TCGA-85-A4JC	LUSC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.1667
p.E1440Q	DO45429	LUSC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.1667
p.N1433Y	TCGA-CR-7370	HNSC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.7059
p.N1433Y	DO14426	HNSC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.7059
p.A1429V	SIDM01129	Small Cell Lung Carcinoma	GDSC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.A1429V	ACH-000816	Lung Cancer	CCLE	SKENG	DEG_APCC_KENBOX_2	0.3056
p.A1429V	NCI-H524	lung	COSMIC	SKENG	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_KENBOX_2	1228:1232	SKENG	APC,CDC20,FZR1	0.8615	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	125:129	SKENG	APC,CDC20,FZR1	0.9622	More...
Q12908	Ileal sodium/bile acid cotransporter	DEG_APCC_KENBOX_2	325:329	SKENG	APC,CDC20,FZR1	0.6472	More...
Q13596	Sorting nexin-1	DEG_APCC_KENBOX_2	72:76	SKENG	APC,CDC20,FZR1	0.924	More...
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_APCC_KENBOX_2	1143:1147	SKENG	APC,CDC20,FZR1	0.9857	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1430:1434	SKENG	APC,CDC20,FZR1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons