DegronMD - Q13596(SNX1)

FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N69I	TCGA-AA-A010	COAD	TCGA	SKENG	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.25
p.L65I	TCGA-DA-A1IB	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1389
p.L65I	DO38033	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1389
p.P85Q	TCGA-EE-A3AG	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.0833
p.P85Q	DO37471	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.0833
p.Q86H	TCGA-IB-7651	PAAD	TCGA	SKENG	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.0556
p.Q86H	DO46657	PAAD	ICGC	SKENG	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.0556
p.P67L	DO232224	PBCA	ICGC	SKENG	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNX1

UniProt ID: Q13596

Entrez ID: 6642

Protein name: Sorting nexin-1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNX1 in