DegronMD

Uniprot ID: Q13596

Source protein: Sorting nexin-1

Source gene: SNX1

Class: DEG_APCC_KENBOX_2

Location: 72:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.924

ASA_SCORE: 90.14

COIL: 0.8452

CONS_SCORE: 0.305

DSS_SCORE: 0.6741

HELIX: 0.1098

FCONS_SCORE: 1.0173

RIG_SCORE: 0.6012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N69I	TCGA-AA-A010	COAD	TCGA	SKENG	DEG_APCC_KENBOX_2	0.25
p.L65I	TCGA-DA-A1IB	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.1389
p.L65I	DO38033	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.1389
p.P85Q	TCGA-EE-A3AG	SKCM	TCGA	SKENG	DEG_APCC_KENBOX_2	0.0833
p.P85Q	DO37471	SKCM	ICGC	SKENG	DEG_APCC_KENBOX_2	0.0833
p.Q86H	TCGA-IB-7651	PAAD	TCGA	SKENG	DEG_APCC_KENBOX_2	0.0556
p.Q86H	DO46657	PAAD	ICGC	SKENG	DEG_APCC_KENBOX_2	0.0556
p.P67L	DO232224	PBCA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_KENBOX_2	1228:1232	SKENG	APC,CDC20,FZR1	0.8615	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	125:129	SKENG	APC,CDC20,FZR1	0.9622	More...
Q12908	Ileal sodium/bile acid cotransporter	DEG_APCC_KENBOX_2	325:329	SKENG	APC,CDC20,FZR1	0.6472	More...
Q13596	Sorting nexin-1	DEG_APCC_KENBOX_2	72:76	SKENG	APC,CDC20,FZR1	0.924	More...
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_APCC_KENBOX_2	1143:1147	SKENG	APC,CDC20,FZR1	0.9857	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1430:1434	SKENG	APC,CDC20,FZR1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons