DegronMD - P35251(RFC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A463T	TCGA-19-5956	GBM	TCGA	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.2222
p.A463T	DO13863	GBM	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.2222
p.Y330S	TCGA-55-8097	LUAD	TCGA	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.0556
p.Y330S	DO25699	LUAD	ICGC	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.0556
p.R452L	TCGA-64-1676	LUAD	TCGA	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.3056
p.R452L	DO23629	LUAD	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.3056
p.R505K	TCGA-86-8668	LUAD	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation altering degron motif	0.6126
p.R505K	DO25669	LUAD	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation altering degron motif	0.6126
p.S338L	TCGA-AA-3949	COAD	TCGA	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2778
p.S338L	DO7798	COAD	ICGC	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2778
p.K509T	TCGA-AA-3984	COAD	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation altering degron motif	0.7306
p.K509T	DO9002	COAD	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation altering degron motif	0.7306
p.K498N	TCGA-AG-A002	READ	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation blocking ubiquitination signal	0.6667
p.R515I	TCGA-AJ-A3EL	UCEC	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667
p.R515I	TCGA-AX-A05Z	UCEC	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667
p.R515I	DO40884	UCEC	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667
p.R515I	DO41542	UCEC	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667
p.S338P	TCGA-AP-A1DH	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2778
p.S338P	DO43995	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2778
p.N133H	TCGA-AP-A1DV	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.2222
p.N133H	DO43186	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.2222
p.R130I	TCGA-B5-A0JY	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.3056
p.R130I	DO43041	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.3056
p.A121V	TCGA-B5-A3FC	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.2222
p.A121V	DO41871	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.2222
p.P354A	TCGA-BC-A10U	LIHC	TCGA	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.0556
p.P354A	DO22926	LIHC	ICGC	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.0556
p.R505I	TCGA-CA-6717	COAD	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation altering degron motif	0.6991
p.R505I	DO8264	COAD	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation altering degron motif	0.6991
p.D115N	TCGA-D1-A160	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.0556
p.D115N	DO41626	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.0556
p.A337T	TCGA-F5-6814	READ	TCGA	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.25
p.A337T	DO36556	READ	ICGC	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.25
p.P519L	TCGA-GN-A8LK	SKCM	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.0556
p.P519L	DO51259	SKCM	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.0556
p.Q512L	DO228202	LICA	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.25
p.L448I	DO228948	LICA	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.1944
p.Q456K	DO228952	LICA	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation altering degron motif	0.5833
p.H135N	DO229022	LICA	ICGC	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.1667
p.S501Y	DO229045	LICA	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.3056
p.G451V	DO231518	LINC	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.2778
p.G129E	DO230538	LUSC	ICGC	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation altering degron motif	0.6087
p.N133D	DO229232	THCA	ICGC	SKENG	DEG_APCC_KENBOX_2	125:129	Mutation rewiring degron network	0.2222
p.Q508P	SIDM00845	Burkitt's Lymphoma	GDSC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation altering degron motif	0.5924
p.Q508P	Daudi	haematopoietic and lymphoid tissue	COSMIC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation altering degron motif	0.5924
p.K346R	SIDM00454	Rhabdomyosarcoma	GDSC	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2778
p.K346R	SIDM01590	Breast Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	340:344	Mutation rewiring degron network	0.2778
p.E496D	SIDM00564	Ovarian Carcinoma	GDSC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667
p.E496D	OVISE	ovary	COSMIC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667
p.E496G	SIDM00564	Ovarian Carcinoma	GDSC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667
p.E496G	OVISE	ovary	COSMIC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667
p.G466E	SIDM01088	Endometrial Carcinoma	GDSC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.1389
p.G466E	ACH-000965	Endometrial/Uterine Cancer	CCLE	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.1389
p.G466E	RL95-2	endometrium	COSMIC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.1389
p.R452C	SIDM00053	Pancreatic Carcinoma	GDSC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.3056
p.R452C	ACH-002164	Pancreatic Cancer	CCLE	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.3056
p.R452C	MZ1-PC	pancreas	COSMIC	DSGQSKS	DEG_SCF_TRCP1_1	453:459	Mutation rewiring degron network	0.3056
p.R515K	ACH-001991	Primary	CCLE	KLERTPQK	DEG_SCF_SKP2-CKS1_1	502:509	Mutation rewiring degron network	0.1667

Kaplan plot for RFC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFC1

UniProt ID: P35251

Entrez ID: 5981

Protein name: Replication factor C subunit 1 (Activator 1 140 kDa subunit) (A1 140 kDa subunit) (Activator 1 large subunit) (Activator 1 subunit 1) (DNA-binding protein PO-GA) (Replication factor C 140 kDa subunit) (RF-C 140 kDa subunit) (RFC140) (Replication factor C large subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFC1 in