DegronMD

Uniprot ID: P35251

Source protein: Replication factor C subunit 1

Source gene: RFC1

Class: DEG_SCF_TRCP1_1

Location: 453:459

E3 ligase: BTRC

DEGRON score: 0.9582

ASA_SCORE: 74.0714

COIL: 0.7104

CONS_SCORE: 0.3972

DSS_SCORE: 0.4433

HELIX: 0.2233

FCONS_SCORE: 1.0097

RIG_SCORE: 0.6891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A463T	TCGA-19-5956	GBM	TCGA	DSGQSKS	DEG_SCF_TRCP1_1	0.2222
p.A463T	DO13863	GBM	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	0.2222
p.R452L	TCGA-64-1676	LUAD	TCGA	DSGQSKS	DEG_SCF_TRCP1_1	0.3056
p.R452L	DO23629	LUAD	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	0.3056
p.L448I	DO228948	LICA	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	0.1944
p.Q456K	DO228952	LICA	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	0.5833
p.G451V	DO231518	LINC	ICGC	DSGQSKS	DEG_SCF_TRCP1_1	0.2778
p.G466E	SIDM01088	Endometrial Carcinoma	GDSC	DSGQSKS	DEG_SCF_TRCP1_1	0.1389
p.G466E	ACH-000965	Endometrial/Uterine Cancer	CCLE	DSGQSKS	DEG_SCF_TRCP1_1	0.1389
p.G466E	RL95-2	endometrium	COSMIC	DSGQSKS	DEG_SCF_TRCP1_1	0.1389
p.R452C	SIDM00053	Pancreatic Carcinoma	GDSC	DSGQSKS	DEG_SCF_TRCP1_1	0.3056
p.R452C	ACH-002164	Pancreatic Cancer	CCLE	DSGQSKS	DEG_SCF_TRCP1_1	0.3056
p.R452C	MZ1-PC	pancreas	COSMIC	DSGQSKS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35251	Replication factor C subunit 1	DEG_SCF_TRCP1_1	453:459	DSGQSKS	BTRC	0.9582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons