DegronMD

Uniprot ID: P35251

Source protein: Replication factor C subunit 1

Source gene: RFC1

Class: DEG_SCF_SKP2-CKS1_1

Location: 502:509

E3 ligase: SKP2,CSK1

DEGRON score: 0.9656

ASA_SCORE: 109.7125

COIL: 0.7086

CONS_SCORE: 0.2557

DSS_SCORE: 0.6735

HELIX: 0.2273

FCONS_SCORE: 1.0329

RIG_SCORE: 0.6919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R505K	TCGA-86-8668	LUAD	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.6126
p.R505K	DO25669	LUAD	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.6126
p.K509T	TCGA-AA-3984	COAD	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.7306
p.K509T	DO9002	COAD	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.7306
p.K498N	TCGA-AG-A002	READ	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.6667
p.R515I	TCGA-AJ-A3EL	UCEC	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R515I	TCGA-AX-A05Z	UCEC	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R515I	DO40884	UCEC	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R515I	DO41542	UCEC	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R505I	TCGA-CA-6717	COAD	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.6991
p.R505I	DO8264	COAD	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.6991
p.P519L	TCGA-GN-A8LK	SKCM	TCGA	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.P519L	DO51259	SKCM	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.0556
p.Q512L	DO228202	LICA	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.25
p.S501Y	DO229045	LICA	ICGC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.3056
p.Q508P	SIDM00845	Burkitt's Lymphoma	GDSC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.5924
p.Q508P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.5924
p.E496D	SIDM00564	Ovarian Carcinoma	GDSC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E496D	OVISE	ovary	COSMIC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E496G	SIDM00564	Ovarian Carcinoma	GDSC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.E496G	OVISE	ovary	COSMIC	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667
p.R515K	ACH-001991	Primary	CCLE	KLERTPQK	DEG_SCF_SKP2-CKS1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35251	Replication factor C subunit 1	DEG_SCF_SKP2-CKS1_1	502:509	KLERTPQK	SKP2,CSK1	0.9656	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons