DegronMD

Uniprot ID: P35251

Source protein: Replication factor C subunit 1

Source gene: RFC1

Class: DEG_APCC_KENBOX_2

Location: 340:344

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8832

ASA_SCORE: 105.3

COIL: 0.5526

CONS_SCORE: 0.2397

DSS_SCORE: 0.5406

HELIX: 0.4224

FCONS_SCORE: 0.9923

RIG_SCORE: 0.7168

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y330S	TCGA-55-8097	LUAD	TCGA	RKENA	DEG_APCC_KENBOX_2	0.0556
p.Y330S	DO25699	LUAD	ICGC	RKENA	DEG_APCC_KENBOX_2	0.0556
p.S338L	TCGA-AA-3949	COAD	TCGA	RKENA	DEG_APCC_KENBOX_2	0.2778
p.S338L	DO7798	COAD	ICGC	RKENA	DEG_APCC_KENBOX_2	0.2778
p.S338P	TCGA-AP-A1DH	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.2778
p.S338P	DO43995	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.2778
p.P354A	TCGA-BC-A10U	LIHC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.0556
p.P354A	DO22926	LIHC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.0556
p.A337T	TCGA-F5-6814	READ	TCGA	RKENA	DEG_APCC_KENBOX_2	0.25
p.A337T	DO36556	READ	ICGC	RKENA	DEG_APCC_KENBOX_2	0.25
p.K346R	SIDM00454	Rhabdomyosarcoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.2778
p.K346R	SIDM01590	Breast Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.9305	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	340:344	RKENA	APC,CDC20,FZR1	0.8832	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_APCC_KENBOX_2	225:229	RKENA	APC,CDC20,FZR1	0.9975	More...
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.932	More...
A4FU28	cTAGE family member 9	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.638	More...
P0CG41	cTAGE family member 8	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...
Q86UF2	cTAGE family member 6	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6768	More...
Q8IX94	cTAGE family member 4	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons