DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
RKENA
Uniprot ID:
Q8IX94
Source protein:
cTAGE family member 4
Source gene:
CTAGE4
Class:
DEG_APCC_KENBOX_2
Location:
480:484
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6456
ASA_SCORE:
98.08
COIL:
0.0452
CONS_SCORE:
0.8052
DSS_SCORE:
0.5074
HELIX:
0.9568
FCONS_SCORE:
1.0959
RIG_SCORE:
0.6927
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CTAGE4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RKENA
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00425
Insulin-like growth factor 2 mRNA-binding protein 3
DEG_APCC_KENBOX_2
233:237
RKENA
APC,CDC20,FZR1
0.9305
More...
P35251
Replication factor C subunit 1
DEG_APCC_KENBOX_2
340:344
RKENA
APC,CDC20,FZR1
0.8832
More...
Q5JTC6
APC membrane recruitment protein 1
DEG_APCC_KENBOX_2
225:229
RKENA
APC,CDC20,FZR1
0.9975
More...
Q9NZI8
Insulin-like growth factor 2 mRNA-binding protein 1
DEG_APCC_KENBOX_2
233:237
RKENA
APC,CDC20,FZR1
0.932
More...
A4FU28
cTAGE family member 9
DEG_APCC_KENBOX_2
480:484
RKENA
APC,CDC20,FZR1
0.638
More...
P0CG41
cTAGE family member 8
DEG_APCC_KENBOX_2
480:484
RKENA
APC,CDC20,FZR1
0.6456
More...
Q86UF2
cTAGE family member 6
DEG_APCC_KENBOX_2
480:484
RKENA
APC,CDC20,FZR1
0.6768
More...
Q8IX94
cTAGE family member 4
DEG_APCC_KENBOX_2
480:484
RKENA
APC,CDC20,FZR1
0.6456
More...