DegronMD

Uniprot ID: O00425

Source protein: Insulin-like growth factor 2 mRNA-binding protein 3

Source gene: IGF2BP3

Class: DEG_APCC_KENBOX_2

Location: 233:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9305

ASA_SCORE: 115.08

COIL: 0.8514

CONS_SCORE: 0.5783

DSS_SCORE: 0.4564

HELIX: 0.0718

FCONS_SCORE: 0.9591

RIG_SCORE: 0.7405

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A237V	TCGA-A5-A0G2	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A237V	TCGA-AG-A002	READ	TCGA	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A237V	TCGA-EO-A22U	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A237V	DO234230	ESAD	ICGC	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A237V	DO233115	GACA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A237V	DO41235	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A237V	DO43755	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A240D	TCGA-AA-A010	COAD	TCGA	RKENA	DEG_APCC_KENBOX_2	0.25
p.Q224H	TCGA-AA-A024	COAD	TCGA	RKENA	DEG_APCC_KENBOX_2	0.0833
p.S227C	TCGA-E5-A2PC	BLCA	TCGA	RKENA	DEG_APCC_KENBOX_2	0.1667
p.S227C	DO702	BLCA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.1667
p.H232N	DO228948	LICA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.3056
p.T225N	DO229015	LICA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.1111
p.R233H	DO35083	PACA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.7133
p.K228I	SIDM00387	Neuroblastoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.6389
p.K228I	MHH-NB-11	autonomic_ganglia	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.9305	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	340:344	RKENA	APC,CDC20,FZR1	0.8832	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_APCC_KENBOX_2	225:229	RKENA	APC,CDC20,FZR1	0.9975	More...
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.932	More...
A4FU28	cTAGE family member 9	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.638	More...
P0CG41	cTAGE family member 8	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...
Q86UF2	cTAGE family member 6	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6768	More...
Q8IX94	cTAGE family member 4	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons