DegronMD

Uniprot ID: A4FU28

Source protein: cTAGE family member 9

Source gene: CTAGE9

Class: DEG_APCC_KENBOX_2

Location: 480:484

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.638

ASA_SCORE: 99.14

COIL: 0.1054

CONS_SCORE: 0.8051

DSS_SCORE: 0.5111

HELIX: 0.8968

FCONS_SCORE: 1.1172

RIG_SCORE: 0.692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A484D	TCGA-A5-A2K5	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.6682
p.A484D	DO41379	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.6682
p.L490I	TCGA-D3-A8GM	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	0.1667
p.L490I	DO50288	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	0.1667
p.E492K	TCGA-LP-A5U2	CESC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.1111
p.E492K	DO51610	CESC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.1111
p.R470Q	DO229218	THCA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.0556
p.R470Q	SIDM00596	Endometrial Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.0556
p.R470W	SIDM00118	Colorectal Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.9305	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	340:344	RKENA	APC,CDC20,FZR1	0.8832	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_APCC_KENBOX_2	225:229	RKENA	APC,CDC20,FZR1	0.9975	More...
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.932	More...
A4FU28	cTAGE family member 9	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.638	More...
P0CG41	cTAGE family member 8	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...
Q86UF2	cTAGE family member 6	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6768	More...
Q8IX94	cTAGE family member 4	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons