DegronMD

Uniprot ID: Q86UF2

Source protein: cTAGE family member 6

Source gene: CTAGE6

Class: DEG_APCC_KENBOX_2

Location: 480:484

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6768

ASA_SCORE: 103.92

COIL: 0.2344

CONS_SCORE: 0.8053

DSS_SCORE: 0.5074

HELIX: 0.7678

FCONS_SCORE: 1.096

RIG_SCORE: 0.6927

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T471I	TCGA-AP-A054	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.0833
p.T471I	DO42256	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.0833
p.E492K	TCGA-D3-A5GN	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	0.1111
p.E492K	DO47317	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	0.1111
p.R480K	TCGA-EB-A3Y7	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	0.6126
p.R480K	DO37499	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	0.6126
p.D478N	TCGA-EE-A2M6	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	0.2778
p.D478N	DO37976	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	0.2778
p.T493R	TCGA-NC-A5HT	LUSC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.0833
p.T493R	DO219205	LUSC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.0833
p.R470Q	DO52343	LUSC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.0556
p.R470Q	SIDM01619	Endometrial Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.9305	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	340:344	RKENA	APC,CDC20,FZR1	0.8832	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_APCC_KENBOX_2	225:229	RKENA	APC,CDC20,FZR1	0.9975	More...
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.932	More...
A4FU28	cTAGE family member 9	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.638	More...
P0CG41	cTAGE family member 8	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...
Q86UF2	cTAGE family member 6	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6768	More...
Q8IX94	cTAGE family member 4	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons