DegronMD - Q86UF2(CTAGE6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T471I	TCGA-AP-A054	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0833
p.T471I	DO42256	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0833
p.E492K	TCGA-D3-A5GN	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1111
p.E492K	DO47317	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1111
p.R480K	TCGA-EB-A3Y7	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.6126
p.R480K	DO37499	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.6126
p.D478N	TCGA-EE-A2M6	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.2778
p.D478N	DO37976	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.2778
p.T493R	TCGA-NC-A5HT	LUSC	TCGA	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0833
p.T493R	DO219205	LUSC	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0833
p.R702S	DO52365	LUSC	ICGC	VRGPLFPVD	DEG_APCC_DBOX_1	701:709	Mutation altering degron motif	0.7427
p.R470Q	DO52343	LUSC	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0556
p.R470Q	SIDM01619	Endometrial Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0556

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons