DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VRGPLFPVD
Uniprot ID:
Q86UF2
Source protein:
cTAGE family member 6
Source gene:
CTAGE6
Class:
DEG_APCC_DBOX_1
Location:
701:709
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9757
ASA_SCORE:
68.8667
COIL:
0.9566
CONS_SCORE:
0.602
DSS_SCORE:
0.5291
HELIX:
0.0151
FCONS_SCORE:
0.9783
RIG_SCORE:
0.6908
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R702S
DO52365
LUSC
ICGC
VRGPLFPVD
DEG_APCC_DBOX_1
0.7427
Drug responses associated with CTAGE6 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VRGPLFPVD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0CG41
cTAGE family member 8
DEG_APCC_DBOX_1
701:709
VRGPLFPVD
APC,CDC20,FZR1
0.9687
More...
Q86UF2
cTAGE family member 6
DEG_APCC_DBOX_1
701:709
VRGPLFPVD
APC,CDC20,FZR1
0.9757
More...