DegronMD

Uniprot ID: P0CG41

Source protein: cTAGE family member 8

Source gene: CTAGE8

Class: DEG_APCC_DBOX_1

Location: 701:709

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9687

ASA_SCORE: 62.3333

COIL: 0.9513

CONS_SCORE: 0.6016

DSS_SCORE: 0.5291

HELIX: 0.016

FCONS_SCORE: 0.9781

RIG_SCORE: 0.6908

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F693L	DO224761	COCA	ICGC	VRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.F693L	DO234285	ESAD	ICGC	VRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.F693L	DO229346	LAML	ICGC	VRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.F693L	DO52363	LUSC	ICGC	VRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.F693L	DO229216	THCA	ICGC	VRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.M715I	DO220875	MELA	ICGC	VRGPLFPVD	DEG_APCC_DBOX_1	0.1667
p.P695L	ACH-000354	Pancreatic Cancer	CCLE	VRGPLFPVD	DEG_APCC_DBOX_1	0.1667
p.G712D	ACH-000998	Colon/Colorectal Cancer	CCLE	VRGPLFPVD	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons