DegronMD

Uniprot ID: Q5JTC6

Source protein: APC membrane recruitment protein 1

Source gene: AMER1

Class: DEG_APCC_KENBOX_2

Location: 225:229

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9975

ASA_SCORE: 113.14

COIL: 0.7904

CONS_SCORE: 0.6302

DSS_SCORE: 0.7635

HELIX: 0.1718

FCONS_SCORE: 1.215

RIG_SCORE: 0.5958

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A223D	TCGA-12-0778	GBM	TCGA	RKENA	DEG_APCC_KENBOX_2	0.2778
p.A223D	DO11411	GBM	ICGC	RKENA	DEG_APCC_KENBOX_2	0.2778
p.P215S	TCGA-AD-6895	COAD	TCGA	RKENA	DEG_APCC_KENBOX_2	0.0556
p.P215S	DO8938	COAD	ICGC	RKENA	DEG_APCC_KENBOX_2	0.0556
p.R225I	TCGA-AG-A002	READ	TCGA	RKENA	DEG_APCC_KENBOX_2	0.6991
p.P235T	TCGA-AP-A059	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.1667
p.P235T	DO41361	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.1667
p.P224T	TCGA-B5-A1MX	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.3056
p.P224T	DO41999	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.3056
p.E227K	TCGA-BF-AAP7	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	0.7022
p.E227K	TCGA-EE-A182	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	0.7022
p.E227K	DO37814	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	0.7022
p.E227K	DO219472	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	0.7022
p.E227K	SIDM00663	Melanoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.7022
p.E227K	ACH-000814	Skin Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	0.7022
p.E227K	Hs939-T	skin	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.7022
p.K238N	DO233906	GACA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.1944
p.P224S	DO220906	MELA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.3056
p.D233G	SIDM01002	Breast Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.2222
p.D233G	ACH-000117	Breast Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	0.2222
p.D233G	EFM-192A	breast	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.2222
p.A229V	SIDM00585	Hepatocellular Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A229V	ACH-000480	Liver Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A229V	HuH-7	liver	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.5825
p.R225S	SIDM00150	Colorectal Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.6316
p.R225S	ACH-000969	Colon/Colorectal Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	0.6316
p.R225S	KM12	large_intestine	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.6316
p.P224H	ACH-001145	Ovarian Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.9305	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	340:344	RKENA	APC,CDC20,FZR1	0.8832	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_APCC_KENBOX_2	225:229	RKENA	APC,CDC20,FZR1	0.9975	More...
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.932	More...
A4FU28	cTAGE family member 9	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.638	More...
P0CG41	cTAGE family member 8	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...
Q86UF2	cTAGE family member 6	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6768	More...
Q8IX94	cTAGE family member 4	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENA

Degron related mutations and impact score

Drug responses associated with AMER1 mutations

All proteins holding degron of RKENA