DegronMD

Uniprot ID: Q9NZI8

Source protein: Insulin-like growth factor 2 mRNA-binding protein 1

Source gene: IGF2BP1

Class: DEG_APCC_KENBOX_2

Location: 233:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.932

ASA_SCORE: 115.96

COIL: 0.8336

CONS_SCORE: 0.5132

DSS_SCORE: 0.4722

HELIX: 0.0712

FCONS_SCORE: 0.8649

RIG_SCORE: 0.73

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A237V	TCGA-99-8033	LUAD	TCGA	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A237V	DO23726	LUAD	ICGC	RKENA	DEG_APCC_KENBOX_2	0.5825
p.A237T	TCGA-AG-A002	READ	TCGA	RKENA	DEG_APCC_KENBOX_2	0.6028
p.A237T	SIDM00680	Colorectal Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.6028
p.A237T	SIDM00327	Hodgkin's Lymphoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.6028
p.A237T	ACH-000754	Lymphoma	CCLE	RKENA	DEG_APCC_KENBOX_2	0.6028
p.A237T	ACH-000957	Colon/Colorectal Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	0.6028
p.A237T	LS-180	large_intestine	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.6028
p.A237T	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.6028
p.K228E	TCGA-B5-A5OC	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.6389
p.K228E	DO52405	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	0.6389
p.A240T	TCGA-B6-A0I2	BRCA	TCGA	RKENA	DEG_APCC_KENBOX_2	0.25
p.A240T	DO1885	BRCA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.25
p.D230E	TCGA-OR-A5KT	ACC	TCGA	RKENA	DEG_APCC_KENBOX_2	0.25
p.A240D	DO227745	COCA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.25
p.I229K	DO228585	LICA	ICGC	RKENA	DEG_APCC_KENBOX_2	0.2222
p.R233K	SIDM00140	Melanoma	GDSC	RKENA	DEG_APCC_KENBOX_2	0.6126
p.R233K	ACH-000968	Skin Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	0.6126
p.R233K	COLO-792	skin	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.6126
p.H224R	Sarc9371	bone	COSMIC	RKENA	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.9305	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	340:344	RKENA	APC,CDC20,FZR1	0.8832	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_APCC_KENBOX_2	225:229	RKENA	APC,CDC20,FZR1	0.9975	More...
Q9NZI8	Insulin-like growth factor 2 mRNA-binding protein 1	DEG_APCC_KENBOX_2	233:237	RKENA	APC,CDC20,FZR1	0.932	More...
A4FU28	cTAGE family member 9	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.638	More...
P0CG41	cTAGE family member 8	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...
Q86UF2	cTAGE family member 6	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6768	More...
Q8IX94	cTAGE family member 4	DEG_APCC_KENBOX_2	480:484	RKENA	APC,CDC20,FZR1	0.6456	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons