DegronMD - O00425(IGF2BP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R181M	TCGA-13-0894	OV	TCGA	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.0833
p.R181M	DO28591	OV	ICGC	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.0833
p.A442V	TCGA-2W-A8YY	CESC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.6936
p.A442V	DO223732	CESC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.6936
p.A442G	TCGA-66-2769	LUSC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.754
p.A442G	DO26522	LUSC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.754
p.E461Q	TCGA-98-8021	LUSC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1111
p.E461Q	DO27468	LUSC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1111
p.A237V	TCGA-A5-A0G2	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation altering degron motif	0.5825
p.A237V	TCGA-AG-A002	READ	TCGA	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation altering degron motif	0.5825
p.A237V	TCGA-EO-A22U	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation altering degron motif	0.5825
p.A237V	DO234230	ESAD	ICGC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation altering degron motif	0.5825
p.A237V	DO233115	GACA	ICGC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation altering degron motif	0.5825
p.A237V	DO41235	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation altering degron motif	0.5825
p.A237V	DO43755	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation altering degron motif	0.5825
p.A240D	TCGA-AA-A010	COAD	TCGA	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation rewiring degron network	0.25
p.A240D	TCGA-AA-A010	COAD	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation rewiring degron network	0.1667
p.Q224H	TCGA-AA-A024	COAD	TCGA	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation rewiring degron network	0.0833
p.A435T	TCGA-AP-A1DK	UCEC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1667
p.A435T	DO42033	UCEC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1667
p.A255T	TCGA-AX-A1CE	UCEC	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation rewiring degron network	0.2778
p.A255T	DO42280	UCEC	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation rewiring degron network	0.2778
p.L247F	TCGA-B5-A0JY	UCEC	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation altering degron motif	0.587
p.L247F	DO43041	UCEC	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation altering degron motif	0.587
p.A160T	TCGA-CM-6679	COAD	TCGA	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.1944
p.A160T	DO8272	COAD	ICGC	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.1944
p.A160T	DO231086	LUSC	ICGC	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.1944
p.M453L	TCGA-D5-6931	COAD	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.5999
p.M453L	DO8384	COAD	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.5999
p.A444T	TCGA-DF-A2KN	UCEC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.6028
p.A444T	DO223282	UCEC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.6028
p.E262D	TCGA-DF-A2KU	UCEC	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation rewiring degron network	0.0833
p.E262D	DO223286	UCEC	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation rewiring degron network	0.0833
p.R171H	TCGA-DF-A2KU	UCEC	TCGA	LQQPRGRR	SCF_FBXL2	165:172	Mutation altering degron motif	0.7133
p.R171H	DO223286	UCEC	ICGC	LQQPRGRR	SCF_FBXL2	165:172	Mutation altering degron motif	0.7133
p.L261M	TCGA-DF-A2KV	UCEC	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation rewiring degron network	0.1111
p.L261M	DO219771	UCEC	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation rewiring degron network	0.1111
p.S227C	TCGA-E5-A2PC	BLCA	TCGA	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation rewiring degron network	0.1667
p.S227C	DO702	BLCA	ICGC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation rewiring degron network	0.1667
p.E461K	TCGA-MA-AA43	CESC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1111
p.E461K	DO219725	CESC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1111
p.E461D	TCGA-UZ-A9PZ	KIRP	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1111
p.E461D	DO219714	KIRP	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1111
p.G175R	TCGA-XF-A9T0	BLCA	TCGA	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.25
p.G175R	DO51920	BLCA	ICGC	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.25
p.V451E	DO228126	EOPC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.7693
p.A444V	DO233752	GACA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.5825
p.H232N	DO228948	LICA	ICGC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation rewiring degron network	0.3056
p.T225N	DO229015	LICA	ICGC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation rewiring degron network	0.1111
p.P460T	DO229035	LICA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1389
p.P459Q	DO229041	LICA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1667
p.P459Q	DO222494	MELA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.1667
p.R172W	DO50823	LICA	ICGC	LQQPRGRR	SCF_FBXL2	165:172	Mutation altering degron motif	0.7523
p.P250S	DO222837	MELA	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation altering degron motif	0.6752
p.I456M	DO232826	NACA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.25
p.R452M	DO232829	NACA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.7521
p.R233H	DO35083	PACA	ICGC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation altering degron motif	0.7133
p.P250L	DO232761	PBCA	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	246:253	Mutation altering degron motif	0.7582
p.R452K	DO229453	SKCA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.6126
p.V454L	DO229213	THCA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation rewiring degron network	0.3056
p.I441L	SIDM02033	Colorectal Carcinoma	GDSC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	441:453	Mutation altering degron motif	0.6063
p.R172Q	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LQQPRGRR	SCF_FBXL2	165:172	Mutation altering degron motif	0.6218
p.R172Q	ACH-000521	Lung Cancer	CCLE	LQQPRGRR	SCF_FBXL2	165:172	Mutation altering degron motif	0.6218
p.R172Q	NCI-H2030	lung	COSMIC	LQQPRGRR	SCF_FBXL2	165:172	Mutation altering degron motif	0.6218
p.K228I	SIDM00387	Neuroblastoma	GDSC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation blocking ubiquitination signal	0.6389
p.K228I	MHH-NB-11	autonomic ganglia	COSMIC	RKENA	DEG_APCC_KENBOX_2	233:237	Mutation blocking ubiquitination signal	0.6389
p.Q182H	SIDM01617	Endometrial Carcinoma	GDSC	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.0556
p.Q182H	ACH-000994	Endometrial/Uterine Cancer	CCLE	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.0556
p.D156N	ACH-000975	Lung Cancer	CCLE	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.0833
p.A164V	639-V	urinary tract	COSMIC	LQQPRGRR	SCF_FBXL2	165:172	Mutation rewiring degron network	0.3056
p.I172L	SNU-C1	large intestine	COSMIC	LQQPRGRR	SCF_FBXL2	165:172	Mutation altering degron motif	0.7174

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGF2BP3

UniProt ID: O00425

Entrez ID: 10643

Protein name: Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGF2BP3 in