DegronMD

Uniprot ID: O00425

Source protein: Insulin-like growth factor 2 mRNA-binding protein 3

Source gene: IGF2BP3

Class: DEG_SCF_FBW7_1

Location: 246:253

E3 ligase: FBXW7

DEGRON score: 0.7052

ASA_SCORE: 43

COIL: 0.3246

CONS_SCORE: 0.6009

DSS_SCORE: 0.371

HELIX: 0.454

FCONS_SCORE: 1.0567

RIG_SCORE: 0.7177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A240D	TCGA-AA-A010	COAD	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	0.1667
p.A255T	TCGA-AX-A1CE	UCEC	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	0.2778
p.A255T	DO42280	UCEC	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	0.2778
p.L247F	TCGA-B5-A0JY	UCEC	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	0.587
p.L247F	DO43041	UCEC	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	0.587
p.E262D	TCGA-DF-A2KU	UCEC	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	0.0833
p.E262D	DO223286	UCEC	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	0.0833
p.L261M	TCGA-DF-A2KV	UCEC	TCGA	ILSTPEGT	DEG_SCF_FBW7_1	0.1111
p.L261M	DO219771	UCEC	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	0.1111
p.P250S	DO222837	MELA	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	0.6752
p.P250L	DO232761	PBCA	ICGC	ILSTPEGT	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	DEG_SCF_FBW7_1	246:253	ILSTPEGT	FBXW7	0.7052	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons