DegronMD

Uniprot ID: O00425

Source protein: Insulin-like growth factor 2 mRNA-binding protein 3

Source gene: IGF2BP3

Class: SCF_FBXL2

Location: 165:172

E3 ligase: FBXL2

DEGRON score: 0.9485

ASA_SCORE: 109.15

COIL: 0.9113

CONS_SCORE: 0.3679

DSS_SCORE: 0.7867

HELIX: 0.0638

FCONS_SCORE: 0.8708

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R181M	TCGA-13-0894	OV	TCGA	LQQPRGRR	SCF_FBXL2	0.0833
p.R181M	DO28591	OV	ICGC	LQQPRGRR	SCF_FBXL2	0.0833
p.A160T	TCGA-CM-6679	COAD	TCGA	LQQPRGRR	SCF_FBXL2	0.1944
p.A160T	DO8272	COAD	ICGC	LQQPRGRR	SCF_FBXL2	0.1944
p.A160T	DO231086	LUSC	ICGC	LQQPRGRR	SCF_FBXL2	0.1944
p.R171H	TCGA-DF-A2KU	UCEC	TCGA	LQQPRGRR	SCF_FBXL2	0.7133
p.R171H	DO223286	UCEC	ICGC	LQQPRGRR	SCF_FBXL2	0.7133
p.G175R	TCGA-XF-A9T0	BLCA	TCGA	LQQPRGRR	SCF_FBXL2	0.25
p.G175R	DO51920	BLCA	ICGC	LQQPRGRR	SCF_FBXL2	0.25
p.R172W	DO50823	LICA	ICGC	LQQPRGRR	SCF_FBXL2	0.7523
p.R172Q	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LQQPRGRR	SCF_FBXL2	0.6218
p.R172Q	ACH-000521	Lung Cancer	CCLE	LQQPRGRR	SCF_FBXL2	0.6218
p.R172Q	NCI-H2030	lung	COSMIC	LQQPRGRR	SCF_FBXL2	0.6218
p.Q182H	SIDM01617	Endometrial Carcinoma	GDSC	LQQPRGRR	SCF_FBXL2	0.0556
p.Q182H	ACH-000994	Endometrial/Uterine Cancer	CCLE	LQQPRGRR	SCF_FBXL2	0.0556
p.D156N	ACH-000975	Lung Cancer	CCLE	LQQPRGRR	SCF_FBXL2	0.0833
p.A164V	639-V	urinary_tract	COSMIC	LQQPRGRR	SCF_FBXL2	0.3056
p.I172L	SNU-C1	large_intestine	COSMIC	LQQPRGRR	SCF_FBXL2	0.7174

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	SCF_FBXL2	165:172	LQQPRGRR	FBXL2	0.9485	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons