DegronMD

Uniprot ID: O00425

Source protein: Insulin-like growth factor 2 mRNA-binding protein 3

Source gene: IGF2BP3

Class: DEG_ODPH_VHL_1

Location: 441:453

E3 ligase: VHL

DEGRON score: 0.8307

ASA_SCORE: 69.3231

COIL: 0.746

CONS_SCORE: 0.5072

DSS_SCORE: 0.2625

HELIX: 0.0903

FCONS_SCORE: 0.8069

RIG_SCORE: 0.7803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A442V	TCGA-2W-A8YY	CESC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.6936
p.A442V	DO223732	CESC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.6936
p.A442G	TCGA-66-2769	LUSC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.754
p.A442G	DO26522	LUSC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.754
p.E461Q	TCGA-98-8021	LUSC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1111
p.E461Q	DO27468	LUSC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1111
p.A435T	TCGA-AP-A1DK	UCEC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1667
p.A435T	DO42033	UCEC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1667
p.M453L	TCGA-D5-6931	COAD	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.5999
p.M453L	DO8384	COAD	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.5999
p.A444T	TCGA-DF-A2KN	UCEC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.6028
p.A444T	DO223282	UCEC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.6028
p.E461K	TCGA-MA-AA43	CESC	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1111
p.E461K	DO219725	CESC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1111
p.E461D	TCGA-UZ-A9PZ	KIRP	TCGA	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1111
p.E461D	DO219714	KIRP	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1111
p.V451E	DO228126	EOPC	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.7693
p.A444V	DO233752	GACA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.5825
p.P460T	DO229035	LICA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1389
p.P459Q	DO229041	LICA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1667
p.P459Q	DO222494	MELA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.1667
p.I456M	DO232826	NACA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.25
p.R452M	DO232829	NACA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.7521
p.R452K	DO229453	SKCA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.6126
p.V454L	DO229213	THCA	ICGC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.3056
p.I441L	SIDM02033	Colorectal Carcinoma	GDSC	IAPAEAPDAKVRM	DEG_ODPH_VHL_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00425	Insulin-like growth factor 2 mRNA-binding protein 3	DEG_ODPH_VHL_1	441:453	IAPAEAPDAKVRM	VHL	0.8307	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IAPAEAPDAKVRM

Degron related mutations and impact score

Drug responses associated with IGF2BP3 mutations

All proteins holding degron of IAPAEAPDAKVRM