DegronMD - A4FU28(CTAGE9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A484D	TCGA-A5-A2K5	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.6682
p.A484D	DO41379	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation altering degron motif	0.6682
p.L490I	TCGA-D3-A8GM	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1667
p.L490I	DO50288	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1667
p.E492K	TCGA-LP-A5U2	CESC	TCGA	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1111
p.E492K	DO51610	CESC	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.1111
p.R470Q	DO229218	THCA	ICGC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0556
p.R470Q	SIDM00596	Endometrial Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0556
p.R470W	SIDM00118	Colorectal Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	480:484	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons