DegronMD - Q5JTC6(AMER1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A223D	TCGA-12-0778	GBM	TCGA	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2778
p.A223D	DO11411	GBM	ICGC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2778
p.D943Y	TCGA-A5-A2K5	UCEC	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.7325
p.D943Y	DO41379	UCEC	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.7325
p.P215S	TCGA-AD-6895	COAD	TCGA	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0556
p.P215S	DO8938	COAD	ICGC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.0556
p.R225I	TCGA-AG-A002	READ	TCGA	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.6991
p.P235T	TCGA-AP-A059	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1667
p.P235T	TCGA-AP-A059	UCEC	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.2222
p.P235T	DO41361	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.1667
p.P235T	DO41361	UCEC	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.2222
p.G290R	TCGA-AP-A0L8	UCEC	TCGA	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation altering degron motif	0.7568
p.G290R	DO42169	UCEC	ICGC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation altering degron motif	0.7568
p.E933K	TCGA-AP-A1DV	UCEC	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0556
p.E933K	DO7801	COAD	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0556
p.E933K	DO43186	UCEC	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0556
p.P224T	TCGA-B5-A1MX	UCEC	TCGA	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.P224T	DO41999	UCEC	ICGC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.W958C	TCGA-BA-6869	HNSC	TCGA	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1389
p.W958C	TCGA-BA-6869	HNSC	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.1944
p.W958C	DO14250	HNSC	ICGC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1389
p.W958C	DO14250	HNSC	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.1944
p.E227K	TCGA-BF-AAP7	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	TCGA-EE-A182	SKCM	TCGA	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	DO37814	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	DO219472	SKCM	ICGC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	SIDM00663	Melanoma	GDSC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	ACH-000814	Skin Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.E227K	Hs939-T	skin	COSMIC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.7022
p.A1040T	TCGA-BH-A203	BRCA	TCGA	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.1111
p.A1040T	DO2156	BRCA	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.1111
p.P953T	TCGA-BR-4362	STAD	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.7031
p.P953T	DO38336	STAD	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.7031
p.E251K	TCGA-C5-A7UH	CESC	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1944
p.E251K	TCGA-ER-A19D	SKCM	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1944
p.E251K	DO49891	CESC	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1944
p.E251K	DO37750	SKCM	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1944
p.E283Q	TCGA-C8-A26Y	BRCA	TCGA	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.25
p.E283Q	DO1273	BRCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.25
p.R942Q	TCGA-CA-6717	COAD	TCGA	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.2222
p.R942Q	TCGA-CA-6717	COAD	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.3056
p.R942Q	DO8264	COAD	ICGC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.2222
p.R942Q	DO8264	COAD	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.3056
p.P243L	TCGA-CQ-6221	HNSC	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.7582
p.P243L	DO14622	HNSC	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.7582
p.V1051M	TCGA-CR-7398	HNSC	TCGA	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation altering degron motif	0.6097
p.V1051M	DO14782	HNSC	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation altering degron motif	0.6097
p.P952H	TCGA-CX-7082	HNSC	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.6583
p.P952H	DO14268	HNSC	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.6583
p.W940R	TCGA-D1-A167	UCEC	TCGA	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1667
p.W940R	TCGA-D1-A167	UCEC	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.25
p.W940R	DO40978	UCEC	ICGC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1667
p.W940R	DO40978	UCEC	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.25
p.P945S	TCGA-D3-A1Q4	SKCM	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.5641
p.P945S	DO47631	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.5641
p.S947F	TCGA-D3-A5GO	SKCM	TCGA	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation altering degron motif	0.6871
p.S947F	TCGA-D3-A5GO	SKCM	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.6871
p.S947F	DO37474	SKCM	ICGC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation altering degron motif	0.6871
p.S947F	DO37474	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.6871
p.S947F	DO47419	SKCM	ICGC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation altering degron motif	0.6871
p.S947F	DO47419	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.6871
p.P241A	TCGA-D8-A1JN	BRCA	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.6392
p.P241A	DO4311	BRCA	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.6392
p.S286R	TCGA-DX-A7ES	SARC	TCGA	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation altering degron motif	0.8538
p.S286R	DO220036	SARC	ICGC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation altering degron motif	0.8538
p.P953S	TCGA-EE-A29G	SKCM	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.6752
p.P953S	DO47303	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation altering degron motif	0.6752
p.G938R	TCGA-EE-A2GS	SKCM	TCGA	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1111
p.G938R	TCGA-EE-A2GS	SKCM	TCGA	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.1944
p.G938R	DO37465	SKCM	ICGC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1111
p.G938R	DO37465	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.1944
p.V293I	TCGA-FJ-A3Z7	BLCA	TCGA	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.2778
p.V293I	DO463	BLCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.2778
p.T242S	TCGA-HU-8602	STAD	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.8227
p.T242S	DO47829	STAD	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.8227
p.P247A	TCGA-J2-A4AD	LUAD	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.3056
p.P247A	DO23915	LUAD	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.3056
p.E288K	TCGA-K4-A5RH	BLCA	TCGA	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation altering degron motif	0.7022
p.E288K	DO219028	BLCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation altering degron motif	0.7022
p.S1059N	TCGA-MA-AA41	CESC	TCGA	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.25
p.S1059N	DO219723	CESC	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.25
p.G1066C	DO233272	GACA	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.0556
p.R942L	DO233641	GACA	ICGC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.2222
p.R942L	DO233641	GACA	ICGC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.3056
p.K238N	DO233906	GACA	ICGC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation substituting flanking lysine	0.1944
p.V239I	DO229026	LICA	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation altering degron motif	0.5965
p.K256E	DO52393	LIHM	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation substituting flanking lysine	0.1667
p.R1045K	DO52695	MALY	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.25
p.P224S	DO220906	MELA	ICGC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056
p.P248T	SIDM01195	Acute Myeloid Leukemia	GDSC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.2778
p.P248T	SIDM01205	Acute Myeloid Leukemia	GDSC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.2778
p.P248T	ACH-000406	Leukemia	CCLE	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.2778
p.P248T	ACH-002314	Leukemia	CCLE	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.2778
p.K292N	SIDM00967	Ovarian Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.3056
p.K292N	SIDM00969	Ovarian Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.3056
p.K292N	SIDM00032	Bladder Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.3056
p.K292N	SIDM00673	Breast Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.3056
p.K292N	SIDM00808	Burkitt's Lymphoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.3056
p.K292N	SIDM00760	Small Cell Lung Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.3056
p.K292N	SIDM01254	Burkitt's Lymphoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.3056
p.S1043G	SIDM00441	Acute Myeloid Leukemia	GDSC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.1944
p.S1043G	ACH-002273	Leukemia	CCLE	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.1944
p.S1043G	ML-2	haematopoietic and lymphoid tissue	COSMIC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.1944
p.D233G	SIDM01002	Breast Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2222
p.D233G	SIDM01002	Breast Carcinoma	GDSC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1667
p.D233G	ACH-000117	Breast Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2222
p.D233G	ACH-000117	Breast Cancer	CCLE	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1667
p.D233G	EFM-192A	breast	COSMIC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.2222
p.D233G	EFM-192A	breast	COSMIC	VSPTPEPS	DEG_SCF_FBW7_1	239:246	Mutation rewiring degron network	0.1667
p.E934K	SIDM00007	Other Solid Cancers	GDSC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0833
p.E934K	ACH-001550	Skin Cancer	CCLE	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0833
p.E934K	MCC13	skin	COSMIC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0833
p.P300T	SIDM00263	Ewing's Sarcoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.0833
p.P300T	ACH-002106	Bone Cancer	CCLE	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.0833
p.P300T	ES5	bone	COSMIC	SPETGE	DEG_Kelch_Keap1_1	286:291	Mutation rewiring degron network	0.0833
p.A229V	SIDM00585	Hepatocellular Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.5825
p.A229V	ACH-000480	Liver Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.5825
p.A229V	HuH-7	liver	COSMIC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.5825
p.G938E	SIDM00251	Gastric Carcinoma	GDSC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1111
p.G938E	SIDM00251	Gastric Carcinoma	GDSC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.1944
p.G938E	ACH-000949	Gastric Cancer	CCLE	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1111
p.G938E	ACH-000949	Gastric Cancer	CCLE	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.1944
p.G938E	TGBC11TKB	stomach	COSMIC	LSLYTE	LIG_APCC_ABBA_1	946:951	Mutation rewiring degron network	0.1111
p.G938E	TGBC11TKB	stomach	COSMIC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.1944
p.R1047M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.3056
p.R1047M	ACH-000826	Lung Cancer	CCLE	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.3056
p.R1047M	CAL-12T	lung	COSMIC	PRDVLLPVD	DEG_APCC_DBOX_1	1048:1056	Mutation rewiring degron network	0.3056
p.E934V	SIDM00217	Colorectal Carcinoma	GDSC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0833
p.E934V	ACH-000999	Colon/Colorectal Cancer	CCLE	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0833
p.E934V	SNU-1040	large intestine	COSMIC	DSPLSLYTEPP	CBL_PTK	943:953	Mutation rewiring degron network	0.0833
p.R225S	SIDM00150	Colorectal Carcinoma	GDSC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.6316
p.R225S	ACH-000969	Colon/Colorectal Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.6316
p.R225S	KM12	large intestine	COSMIC	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation altering degron motif	0.6316
p.P224H	ACH-001145	Ovarian Cancer	CCLE	RKENA	DEG_APCC_KENBOX_2	225:229	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMER1

UniProt ID: Q5JTC6

Entrez ID: 139285

Protein name: APC membrane recruitment protein 1 (Amer1) (Protein FAM123B) (Wilms tumor gene on the X chromosome protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMER1 in