DegronMD

Uniprot ID: Q5JTC6

Source protein: APC membrane recruitment protein 1

Source gene: AMER1

Class: DEG_SCF_FBW7_1

Location: 239:246

E3 ligase: FBXW7

DEGRON score: 0.9384

ASA_SCORE: 92.0125

COIL: 0.9501

CONS_SCORE: 0.4286

DSS_SCORE: 0.7851

HELIX: 0.0124

FCONS_SCORE: 0.7287

RIG_SCORE: 0.5064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P235T	TCGA-AP-A059	UCEC	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	0.2222
p.P235T	DO41361	UCEC	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.2222
p.E251K	TCGA-C5-A7UH	CESC	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	0.1944
p.E251K	TCGA-ER-A19D	SKCM	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	0.1944
p.E251K	DO49891	CESC	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.1944
p.E251K	DO37750	SKCM	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.1944
p.P243L	TCGA-CQ-6221	HNSC	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	0.7582
p.P243L	DO14622	HNSC	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.7582
p.P241A	TCGA-D8-A1JN	BRCA	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	0.6392
p.P241A	DO4311	BRCA	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.6392
p.T242S	TCGA-HU-8602	STAD	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	0.8227
p.T242S	DO47829	STAD	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.8227
p.P247A	TCGA-J2-A4AD	LUAD	TCGA	VSPTPEPS	DEG_SCF_FBW7_1	0.3056
p.P247A	DO23915	LUAD	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.3056
p.V239I	DO229026	LICA	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.5965
p.K256E	DO52393	LIHM	ICGC	VSPTPEPS	DEG_SCF_FBW7_1	0.1667
p.P248T	SIDM01195	Acute Myeloid Leukemia	GDSC	VSPTPEPS	DEG_SCF_FBW7_1	0.2778
p.P248T	SIDM01205	Acute Myeloid Leukemia	GDSC	VSPTPEPS	DEG_SCF_FBW7_1	0.2778
p.P248T	ACH-000406	Leukemia	CCLE	VSPTPEPS	DEG_SCF_FBW7_1	0.2778
p.P248T	ACH-002314	Leukemia	CCLE	VSPTPEPS	DEG_SCF_FBW7_1	0.2778
p.D233G	SIDM01002	Breast Carcinoma	GDSC	VSPTPEPS	DEG_SCF_FBW7_1	0.1667
p.D233G	ACH-000117	Breast Cancer	CCLE	VSPTPEPS	DEG_SCF_FBW7_1	0.1667
p.D233G	EFM-192A	breast	COSMIC	VSPTPEPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTC6	APC membrane recruitment protein 1	DEG_SCF_FBW7_1	239:246	VSPTPEPS	FBXW7	0.9384	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons