DegronMD

Uniprot ID: Q5JTC6

Source protein: APC membrane recruitment protein 1

Source gene: AMER1

Class: CBL_PTK

Location: 943:953

E3 ligase: CBL

DEGRON score: 0.9736

ASA_SCORE: 74.8545

COIL: 0.8518

CONS_SCORE: 0.4026

DSS_SCORE: 0.5859

HELIX: 0.0635

FCONS_SCORE: 1.0368

RIG_SCORE: 0.6728

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D943Y	TCGA-A5-A2K5	UCEC	TCGA	DSPLSLYTEPP	CBL_PTK	0.7325
p.D943Y	DO41379	UCEC	ICGC	DSPLSLYTEPP	CBL_PTK	0.7325
p.E933K	TCGA-AP-A1DV	UCEC	TCGA	DSPLSLYTEPP	CBL_PTK	0.0556
p.E933K	DO7801	COAD	ICGC	DSPLSLYTEPP	CBL_PTK	0.0556
p.E933K	DO43186	UCEC	ICGC	DSPLSLYTEPP	CBL_PTK	0.0556
p.W958C	TCGA-BA-6869	HNSC	TCGA	DSPLSLYTEPP	CBL_PTK	0.1944
p.W958C	DO14250	HNSC	ICGC	DSPLSLYTEPP	CBL_PTK	0.1944
p.P953T	TCGA-BR-4362	STAD	TCGA	DSPLSLYTEPP	CBL_PTK	0.7031
p.P953T	DO38336	STAD	ICGC	DSPLSLYTEPP	CBL_PTK	0.7031
p.R942Q	TCGA-CA-6717	COAD	TCGA	DSPLSLYTEPP	CBL_PTK	0.3056
p.R942Q	DO8264	COAD	ICGC	DSPLSLYTEPP	CBL_PTK	0.3056
p.P952H	TCGA-CX-7082	HNSC	TCGA	DSPLSLYTEPP	CBL_PTK	0.6583
p.P952H	DO14268	HNSC	ICGC	DSPLSLYTEPP	CBL_PTK	0.6583
p.W940R	TCGA-D1-A167	UCEC	TCGA	DSPLSLYTEPP	CBL_PTK	0.25
p.W940R	DO40978	UCEC	ICGC	DSPLSLYTEPP	CBL_PTK	0.25
p.P945S	TCGA-D3-A1Q4	SKCM	TCGA	DSPLSLYTEPP	CBL_PTK	0.5641
p.P945S	DO47631	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	0.5641
p.S947F	TCGA-D3-A5GO	SKCM	TCGA	DSPLSLYTEPP	CBL_PTK	0.6871
p.S947F	DO37474	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	0.6871
p.S947F	DO47419	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	0.6871
p.P953S	TCGA-EE-A29G	SKCM	TCGA	DSPLSLYTEPP	CBL_PTK	0.6752
p.P953S	DO47303	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	0.6752
p.G938R	TCGA-EE-A2GS	SKCM	TCGA	DSPLSLYTEPP	CBL_PTK	0.1944
p.G938R	DO37465	SKCM	ICGC	DSPLSLYTEPP	CBL_PTK	0.1944
p.R942L	DO233641	GACA	ICGC	DSPLSLYTEPP	CBL_PTK	0.3056
p.E934K	SIDM00007	Other Solid Cancers	GDSC	DSPLSLYTEPP	CBL_PTK	0.0833
p.E934K	ACH-001550	Skin Cancer	CCLE	DSPLSLYTEPP	CBL_PTK	0.0833
p.E934K	MCC13	skin	COSMIC	DSPLSLYTEPP	CBL_PTK	0.0833
p.G938E	SIDM00251	Gastric Carcinoma	GDSC	DSPLSLYTEPP	CBL_PTK	0.1944
p.G938E	ACH-000949	Gastric Cancer	CCLE	DSPLSLYTEPP	CBL_PTK	0.1944
p.G938E	TGBC11TKB	stomach	COSMIC	DSPLSLYTEPP	CBL_PTK	0.1944
p.E934V	SIDM00217	Colorectal Carcinoma	GDSC	DSPLSLYTEPP	CBL_PTK	0.0833
p.E934V	ACH-000999	Colon/Colorectal Cancer	CCLE	DSPLSLYTEPP	CBL_PTK	0.0833
p.E934V	SNU-1040	large_intestine	COSMIC	DSPLSLYTEPP	CBL_PTK	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSPLSLYTEPP

Degron related mutations and impact score

Drug responses associated with AMER1 mutations

All proteins holding degron of DSPLSLYTEPP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTC6	APC membrane recruitment protein 1	CBL_PTK	943:953	DSPLSLYTEPP	CBL	0.9736	More...