DegronMD

Uniprot ID: Q5JTC6

Source protein: APC membrane recruitment protein 1

Source gene: AMER1

Class: DEG_Kelch_Keap1_1

Location: 286:291

E3 ligase: KEAP1

DEGRON score: 0.9946

ASA_SCORE: 76.3

COIL: 0.8433

CONS_SCORE: 0.5841

DSS_SCORE: 0.7248

HELIX: 0.123

FCONS_SCORE: 0.9908

RIG_SCORE: 0.5758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G290R	TCGA-AP-A0L8	UCEC	TCGA	SPETGE	DEG_Kelch_Keap1_1	0.7568
p.G290R	DO42169	UCEC	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.7568
p.E283Q	TCGA-C8-A26Y	BRCA	TCGA	SPETGE	DEG_Kelch_Keap1_1	0.25
p.E283Q	DO1273	BRCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.25
p.S286R	TCGA-DX-A7ES	SARC	TCGA	SPETGE	DEG_Kelch_Keap1_1	0.8538
p.S286R	DO220036	SARC	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.8538
p.V293I	TCGA-FJ-A3Z7	BLCA	TCGA	SPETGE	DEG_Kelch_Keap1_1	0.2778
p.V293I	DO463	BLCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.2778
p.E288K	TCGA-K4-A5RH	BLCA	TCGA	SPETGE	DEG_Kelch_Keap1_1	0.7022
p.E288K	DO219028	BLCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.7022
p.K292N	SIDM00967	Ovarian Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.3056
p.K292N	SIDM00969	Ovarian Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.3056
p.K292N	SIDM00032	Bladder Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.3056
p.K292N	SIDM00673	Breast Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.3056
p.K292N	SIDM00808	Burkitt's Lymphoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.3056
p.K292N	SIDM00760	Small Cell Lung Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.3056
p.K292N	SIDM01254	Burkitt's Lymphoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.3056
p.P300T	SIDM00263	Ewing's Sarcoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.0833
p.P300T	ACH-002106	Bone Cancer	CCLE	SPETGE	DEG_Kelch_Keap1_1	0.0833
p.P300T	ES5	bone	COSMIC	SPETGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08174	Protocadherin-1	DEG_Kelch_Keap1_1	558:563	SPETGE	KEAP1	0.9864	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_Kelch_Keap1_1	286:291	SPETGE	KEAP1	0.9946	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_Kelch_Keap1_1	375:380	SPETGE	KEAP1	0.8975	More...
Q9NP08	Homeobox protein HMX1	DEG_Kelch_Keap1_1	137:142	SPETGE	KEAP1	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons