DegronMD

Uniprot ID: Q08174

Source protein: Protocadherin-1

Source gene: PCDH1

Class: DEG_Kelch_Keap1_1

Location: 558:563

E3 ligase: KEAP1

DEGRON score: 0.9864

ASA_SCORE: 56.35

COIL: 0.7205

CONS_SCORE: 0.6405

DSS_SCORE: 0.4347

HELIX: 0.0185

FCONS_SCORE: 1.0903

RIG_SCORE: 0.7327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L570V	TCGA-B0-4698	KIRC	TCGA	SPETGE	DEG_Kelch_Keap1_1	0.1389
p.L570V	DO20368	KIRC	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.1389
p.S569T	TCGA-GS-A9TT	DLBC	TCGA	SPETGE	DEG_Kelch_Keap1_1	0.1667
p.S569T	DO219912	DLBC	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.1667
p.R572W	DO234235	ESAD	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.0833
p.R572W	DO27851	MALY	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.0833
p.T568A	DO229051	LICA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.1944
p.A551V	DO23428	LINC	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.1389
p.T568K	SIDM00124	Kidney Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	0.1944
p.T568K	ACH-000555	Kidney Cancer	CCLE	SPETGE	DEG_Kelch_Keap1_1	0.1944
p.T568K	A498	kidney	COSMIC	SPETGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08174	Protocadherin-1	DEG_Kelch_Keap1_1	558:563	SPETGE	KEAP1	0.9864	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_Kelch_Keap1_1	286:291	SPETGE	KEAP1	0.9946	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_Kelch_Keap1_1	375:380	SPETGE	KEAP1	0.8975	More...
Q9NP08	Homeobox protein HMX1	DEG_Kelch_Keap1_1	137:142	SPETGE	KEAP1	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons