DegronMD - Q08174(PCDH1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1023L	TCGA-69-7978	LUAD	TCGA	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.25
p.R1023L	DO24920	LUAD	ICGC	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.25
p.R1023S	TCGA-77-7465	LUSC	TCGA	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.25
p.R1023S	DO27699	LUSC	ICGC	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.25
p.L570V	TCGA-B0-4698	KIRC	TCGA	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1389
p.L570V	DO20368	KIRC	ICGC	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1389
p.P1030T	TCGA-EI-6882	READ	TCGA	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.3056
p.P1030T	DO36531	READ	ICGC	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.3056
p.R1023H	TCGA-F1-6874	STAD	TCGA	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.25
p.R1023H	DO38201	STAD	ICGC	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.25
p.S569T	TCGA-GS-A9TT	DLBC	TCGA	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1667
p.S569T	DO219912	DLBC	ICGC	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1667
p.S1031N	TCGA-VQ-A91K	STAD	TCGA	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.2778
p.S1031N	DO51785	STAD	ICGC	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.2778
p.S1018F	TCGA-WE-A8ZT	SKCM	TCGA	PPKY	ITCH	1026:1029	Mutation blocking phosphorylation signal	0.5556
p.S1018F	DO51290	SKCM	ICGC	PPKY	ITCH	1026:1029	Mutation blocking phosphorylation signal	0.5556
p.R572W	DO234235	ESAD	ICGC	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.0833
p.R572W	DO27851	MALY	ICGC	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.0833
p.S1031R	DO229015	LICA	ICGC	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.2778
p.P1030H	DO229015	LICA	ICGC	PPKY	ITCH	1026:1029	Mutation rewiring degron network	0.3056
p.T568A	DO229051	LICA	ICGC	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1944
p.A551V	DO23428	LINC	ICGC	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1389
p.T568K	SIDM00124	Kidney Carcinoma	GDSC	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1944
p.T568K	ACH-000555	Kidney Cancer	CCLE	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1944
p.T568K	A498	kidney	COSMIC	SPETGE	DEG_Kelch_Keap1_1	558:563	Mutation rewiring degron network	0.1944
p.K1028N	ACH-001119	Lymphoma	CCLE	PPKY	ITCH	1026:1029	Mutation altering degron motif	0.5806

Kaplan plot for PCDH1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDH1

UniProt ID: Q08174

Entrez ID: 5097

Protein name: Protocadherin-1 (Cadherin-like protein 1) (Protocadherin-42) (PC42)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDH1 in