DegronMD

Uniprot ID: Q9NQV8

Source protein: PR domain zinc finger protein 8

Source gene: PRDM8

Class: DEG_Kelch_Keap1_1

Location: 375:380

E3 ligase: KEAP1

DEGRON score: 0.8975

ASA_SCORE: 82.3833

COIL: 0.8278

CONS_SCORE: 0.5768

DSS_SCORE: 0.5175

HELIX: 0.14

FCONS_SCORE: 1.0265

RIG_SCORE: 0.629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S384I	DO227987	COCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.2222
p.G368D	DO222765	COCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.1389
p.A372V	DO233864	GACA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08174	Protocadherin-1	DEG_Kelch_Keap1_1	558:563	SPETGE	KEAP1	0.9864	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_Kelch_Keap1_1	286:291	SPETGE	KEAP1	0.9946	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_Kelch_Keap1_1	375:380	SPETGE	KEAP1	0.8975	More...
Q9NP08	Homeobox protein HMX1	DEG_Kelch_Keap1_1	137:142	SPETGE	KEAP1	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons