DegronMD

Uniprot ID: Q9NP08

Source protein: Homeobox protein HMX1

Source gene: HMX1

Class: DEG_Kelch_Keap1_1

Location: 137:142

E3 ligase: KEAP1

DEGRON score: 0.9676

ASA_SCORE: 66.5167

COIL: 0.7722

CONS_SCORE: 0.5208

DSS_SCORE: 0.7965

HELIX: 0.1997

FCONS_SCORE: 1.0519

RIG_SCORE: 0.5995

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T149A	DO233259	GACA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.1389
p.S133R	DO26553	LUSC	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.2222
p.D152N	DO222546	MELA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.0556
p.A151T	DO222775	MELA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.0833
p.V148L	DO229275	THCA	ICGC	SPETGE	DEG_Kelch_Keap1_1	0.1667
p.P152Q	ACH-000669	Lung Cancer	CCLE	SPETGE	DEG_Kelch_Keap1_1	0.0556
p.G141C	ACH-000852	Lung Cancer	CCLE	SPETGE	DEG_Kelch_Keap1_1	0.76
p.P152L	ACH-000940	Endometrial/Uterine Cancer	CCLE	SPETGE	DEG_Kelch_Keap1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q08174	Protocadherin-1	DEG_Kelch_Keap1_1	558:563	SPETGE	KEAP1	0.9864	More...
Q5JTC6	APC membrane recruitment protein 1	DEG_Kelch_Keap1_1	286:291	SPETGE	KEAP1	0.9946	More...
Q9NQV8	PR domain zinc finger protein 8	DEG_Kelch_Keap1_1	375:380	SPETGE	KEAP1	0.8975	More...
Q9NP08	Homeobox protein HMX1	DEG_Kelch_Keap1_1	137:142	SPETGE	KEAP1	0.9676	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons