DegronMD

Uniprot ID: Q5JTC6

Source protein: APC membrane recruitment protein 1

Source gene: AMER1

Class: DEG_APCC_DBOX_1

Location: 1048:1056

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9511

ASA_SCORE: 67.8444

COIL: 0.6497

CONS_SCORE: 0.4868

DSS_SCORE: 0.6129

HELIX: 0.084

FCONS_SCORE: 1.1919

RIG_SCORE: 0.7178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1040T	TCGA-BH-A203	BRCA	TCGA	PRDVLLPVD	DEG_APCC_DBOX_1	0.1111
p.A1040T	DO2156	BRCA	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	0.1111
p.V1051M	TCGA-CR-7398	HNSC	TCGA	PRDVLLPVD	DEG_APCC_DBOX_1	0.6097
p.V1051M	DO14782	HNSC	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	0.6097
p.S1059N	TCGA-MA-AA41	CESC	TCGA	PRDVLLPVD	DEG_APCC_DBOX_1	0.25
p.S1059N	DO219723	CESC	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	0.25
p.G1066C	DO233272	GACA	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	0.0556
p.R1045K	DO52695	MALY	ICGC	PRDVLLPVD	DEG_APCC_DBOX_1	0.25
p.S1043G	SIDM00441	Acute Myeloid Leukemia	GDSC	PRDVLLPVD	DEG_APCC_DBOX_1	0.1944
p.S1043G	ACH-002273	Leukemia	CCLE	PRDVLLPVD	DEG_APCC_DBOX_1	0.1944
p.S1043G	ML-2	haematopoietic_and_lymphoid_tissue	COSMIC	PRDVLLPVD	DEG_APCC_DBOX_1	0.1944
p.R1047M	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PRDVLLPVD	DEG_APCC_DBOX_1	0.3056
p.R1047M	ACH-000826	Lung Cancer	CCLE	PRDVLLPVD	DEG_APCC_DBOX_1	0.3056
p.R1047M	CAL-12T	lung	COSMIC	PRDVLLPVD	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTC6	APC membrane recruitment protein 1	DEG_APCC_DBOX_1	1048:1056	PRDVLLPVD	APC,CDC20,FZR1	0.9511	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons