DegronMD

Uniprot ID: Q5JTC6

Source protein: APC membrane recruitment protein 1

Source gene: AMER1

Class: LIG_APCC_ABBA_1

Location: 946:951

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9409

ASA_SCORE: 71.85

COIL: 0.7898

CONS_SCORE: 0.4071

DSS_SCORE: 0.5457

HELIX: 0.0767

FCONS_SCORE: 1.0745

RIG_SCORE: 0.6749

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W958C	TCGA-BA-6869	HNSC	TCGA	LSLYTE	LIG_APCC_ABBA_1	0.1389
p.W958C	DO14250	HNSC	ICGC	LSLYTE	LIG_APCC_ABBA_1	0.1389
p.R942Q	TCGA-CA-6717	COAD	TCGA	LSLYTE	LIG_APCC_ABBA_1	0.2222
p.R942Q	DO8264	COAD	ICGC	LSLYTE	LIG_APCC_ABBA_1	0.2222
p.W940R	TCGA-D1-A167	UCEC	TCGA	LSLYTE	LIG_APCC_ABBA_1	0.1667
p.W940R	DO40978	UCEC	ICGC	LSLYTE	LIG_APCC_ABBA_1	0.1667
p.S947F	TCGA-D3-A5GO	SKCM	TCGA	LSLYTE	LIG_APCC_ABBA_1	0.6871
p.S947F	DO37474	SKCM	ICGC	LSLYTE	LIG_APCC_ABBA_1	0.6871
p.S947F	DO47419	SKCM	ICGC	LSLYTE	LIG_APCC_ABBA_1	0.6871
p.G938R	TCGA-EE-A2GS	SKCM	TCGA	LSLYTE	LIG_APCC_ABBA_1	0.1111
p.G938R	DO37465	SKCM	ICGC	LSLYTE	LIG_APCC_ABBA_1	0.1111
p.R942L	DO233641	GACA	ICGC	LSLYTE	LIG_APCC_ABBA_1	0.2222
p.G938E	SIDM00251	Gastric Carcinoma	GDSC	LSLYTE	LIG_APCC_ABBA_1	0.1111
p.G938E	ACH-000949	Gastric Cancer	CCLE	LSLYTE	LIG_APCC_ABBA_1	0.1111
p.G938E	TGBC11TKB	stomach	COSMIC	LSLYTE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JTC6	APC membrane recruitment protein 1	LIG_APCC_ABBA_1	946:951	LSLYTE	APC,CDC20,FZR1	0.9409	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons