DegronMD

Uniprot ID: P35251

Source protein: Replication factor C subunit 1

Source gene: RFC1

Class: DEG_APCC_KENBOX_2

Location: 125:129

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9622

ASA_SCORE: 102.58

COIL: 0.8696

CONS_SCORE: 0.2361

DSS_SCORE: 0.603

HELIX: 0.0738

FCONS_SCORE: 1.0204

RIG_SCORE: 0.5809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N133H	TCGA-AP-A1DV	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.2222
p.N133H	DO43186	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.2222
p.R130I	TCGA-B5-A0JY	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.3056
p.R130I	DO43041	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056
p.A121V	TCGA-B5-A3FC	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.2222
p.A121V	DO41871	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.2222
p.D115N	TCGA-D1-A160	UCEC	TCGA	SKENG	DEG_APCC_KENBOX_2	0.0556
p.D115N	DO41626	UCEC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.0556
p.H135N	DO229022	LICA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.1667
p.G129E	DO230538	LUSC	ICGC	SKENG	DEG_APCC_KENBOX_2	0.6087
p.N133D	DO229232	THCA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_KENBOX_2	1228:1232	SKENG	APC,CDC20,FZR1	0.8615	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	125:129	SKENG	APC,CDC20,FZR1	0.9622	More...
Q12908	Ileal sodium/bile acid cotransporter	DEG_APCC_KENBOX_2	325:329	SKENG	APC,CDC20,FZR1	0.6472	More...
Q13596	Sorting nexin-1	DEG_APCC_KENBOX_2	72:76	SKENG	APC,CDC20,FZR1	0.924	More...
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_APCC_KENBOX_2	1143:1147	SKENG	APC,CDC20,FZR1	0.9857	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1430:1434	SKENG	APC,CDC20,FZR1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons