DegronMD

Uniprot ID: Q8IX12

Source protein: Cell division cycle and apoptosis regulator protein 1

Source gene: CCAR1

Class: DEG_APCC_KENBOX_2

Location: 1143:1147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9857

ASA_SCORE: 99.06

COIL: 0.5738

CONS_SCORE: 0.2822

DSS_SCORE: 0.8435

HELIX: 0.3988

FCONS_SCORE: 1.0644

RIG_SCORE: 0.6463

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1141K	TCGA-BR-8680	STAD	TCGA	SKENG	DEG_APCC_KENBOX_2	0.2778
p.Q1141K	DO47769	STAD	ICGC	SKENG	DEG_APCC_KENBOX_2	0.2778
p.K1135N	TCGA-XF-A9T5	BLCA	TCGA	SKENG	DEG_APCC_KENBOX_2	0.2222
p.K1135N	DO51925	BLCA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.2222
p.A1148S	DO229008	LICA	ICGC	SKENG	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35125	Ubiquitin carboxyl-terminal hydrolase 6	DEG_APCC_KENBOX_2	1228:1232	SKENG	APC,CDC20,FZR1	0.8615	More...
P35251	Replication factor C subunit 1	DEG_APCC_KENBOX_2	125:129	SKENG	APC,CDC20,FZR1	0.9622	More...
Q12908	Ileal sodium/bile acid cotransporter	DEG_APCC_KENBOX_2	325:329	SKENG	APC,CDC20,FZR1	0.6472	More...
Q13596	Sorting nexin-1	DEG_APCC_KENBOX_2	72:76	SKENG	APC,CDC20,FZR1	0.924	More...
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_APCC_KENBOX_2	1143:1147	SKENG	APC,CDC20,FZR1	0.9857	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1430:1434	SKENG	APC,CDC20,FZR1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons