DegronMD - Q8IX12(CCAR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q127H	TCGA-AX-A06F	UCEC	TCGA	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.2778
p.Q127H	TCGA-AX-A06F	UCEC	TCGA	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1667
p.P133A	TCGA-AY-A71X	COAD	TCGA	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.7503
p.P133A	DO51726	COAD	ICGC	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.7503
p.Q1141K	TCGA-BR-8680	STAD	TCGA	SKENG	DEG_APCC_KENBOX_2	1143:1147	Mutation rewiring degron network	0.2778
p.Q1141K	DO47769	STAD	ICGC	SKENG	DEG_APCC_KENBOX_2	1143:1147	Mutation rewiring degron network	0.2778
p.V111F	TCGA-CZ-5453	KIRC	TCGA	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1111
p.P109Q	TCGA-EE-A17Z	SKCM	TCGA	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.0556
p.K1135N	TCGA-XF-A9T5	BLCA	TCGA	SKENG	DEG_APCC_KENBOX_2	1143:1147	Mutation substituting flanking lysine	0.2222
p.K1135N	DO51925	BLCA	ICGC	SKENG	DEG_APCC_KENBOX_2	1143:1147	Mutation substituting flanking lysine	0.2222
p.S123I	DO229031	LICA	ICGC	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation altering degron motif	0.7341
p.K131N	DO229031	LICA	ICGC	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1667
p.K131N	DO229031	LICA	ICGC	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2778
p.R121S	DO229041	LICA	ICGC	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation altering degron motif	0.7427
p.A1148S	DO229008	LICA	ICGC	SKENG	DEG_APCC_KENBOX_2	1143:1147	Mutation rewiring degron network	0.3056
p.P118T	DO232224	PBCA	ICGC	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.3056
p.Q112H	DO41752	UCEC	ICGC	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1389
p.T145M	DO42793	UCEC	ICGC	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1389
p.P144H	SIDM00789	Colorectal Carcinoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1667
p.P144H	ACH-000997	Colon/Colorectal Cancer	CCLE	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1667
p.P144H	HCT-15	large intestine	COSMIC	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.1667
p.P133S	SIDM01060	Melanoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.6752
p.P133S	ACH-000882	Skin Cancer	CCLE	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.6752
p.P133S	IGR-1	skin	COSMIC	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation altering degron motif	0.6752
p.P118S	IGR-1	skin	COSMIC	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.3056
p.P129H	HCT-15	large intestine	COSMIC	LSTPQPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.2222
p.P129H	HCT-15	large intestine	COSMIC	PTPRSS	DEG_SCF_FBW7_1	133:138	Mutation rewiring degron network	0.2222

Kaplan plot for CCAR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCAR1

UniProt ID: Q8IX12

Entrez ID: 55749

Protein name: Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCAR1 in