DegronMD

Uniprot ID: Q8IX12

Source protein: Cell division cycle and apoptosis regulator protein 1

Source gene: CCAR1

Class: DEG_SCF_FBW7_1

Location: 133:138

E3 ligase: FBXW7

DEGRON score: 0.7852

ASA_SCORE: 89.2667

COIL: 0.9213

CONS_SCORE: 0.3814

DSS_SCORE: 0.6433

HELIX: 0.0527

FCONS_SCORE: 0.959

RIG_SCORE: 0.6588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q127H	TCGA-AX-A06F	UCEC	TCGA	PTPRSS	DEG_SCF_FBW7_1	0.1667
p.P133A	TCGA-AY-A71X	COAD	TCGA	PTPRSS	DEG_SCF_FBW7_1	0.7503
p.P133A	DO51726	COAD	ICGC	PTPRSS	DEG_SCF_FBW7_1	0.7503
p.K131N	DO229031	LICA	ICGC	PTPRSS	DEG_SCF_FBW7_1	0.2778
p.T145M	DO42793	UCEC	ICGC	PTPRSS	DEG_SCF_FBW7_1	0.1389
p.P144H	SIDM00789	Colorectal Carcinoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	0.1667
p.P144H	ACH-000997	Colon/Colorectal Cancer	CCLE	PTPRSS	DEG_SCF_FBW7_1	0.1667
p.P144H	HCT-15	large_intestine	COSMIC	PTPRSS	DEG_SCF_FBW7_1	0.1667
p.P133S	SIDM01060	Melanoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	0.6752
p.P133S	ACH-000882	Skin Cancer	CCLE	PTPRSS	DEG_SCF_FBW7_1	0.6752
p.P133S	IGR-1	skin	COSMIC	PTPRSS	DEG_SCF_FBW7_1	0.6752
p.P129H	HCT-15	large_intestine	COSMIC	PTPRSS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_SCF_FBW7_1	133:138	PTPRSS	FBXW7	0.7852	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SCF_FBW7_1	360:365	PTPRSS	FBXW7	0.798	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons