DegronMD

Uniprot ID: Q96F05

Source protein: Uncharacterized protein C11orf24

Source gene: C11orf24

Class: DEG_SCF_FBW7_1

Location: 360:365

E3 ligase: FBXW7

DEGRON score: 0.798

ASA_SCORE: 88.1833

COIL: 0.9328

CONS_SCORE: 0.4798

DSS_SCORE: 0.8159

HELIX: 0.0182

FCONS_SCORE: 0.988

RIG_SCORE: 0.542

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S365P	TCGA-12-1088	GBM	TCGA	PTPRSS	DEG_SCF_FBW7_1	0.6752
p.S365P	DO13701	GBM	ICGC	PTPRSS	DEG_SCF_FBW7_1	0.6752
p.D374V	TCGA-L9-A8F4	LUAD	TCGA	PTPRSS	DEG_SCF_FBW7_1	0.0833
p.D374V	DO49876	LUAD	ICGC	PTPRSS	DEG_SCF_FBW7_1	0.0833
p.R363G	DO5745	BRCA	ICGC	PTPRSS	DEG_SCF_FBW7_1	0.6457
p.S375L	SIDM02021	Esophageal Carcinoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	0.0556
p.S375L	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	0.0556
p.S375L	ACH-002253	Lymphoma	CCLE	PTPRSS	DEG_SCF_FBW7_1	0.0556
p.T361I	SIDM01126	Small Cell Lung Carcinoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	0.7078
p.T361I	SIDM00257	Neuroblastoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	0.7078
p.T361I	SIDM01752	Pancreatic Carcinoma	GDSC	PTPRSS	DEG_SCF_FBW7_1	0.7078
p.S364N	ACH-000338	Lymphoma	CCLE	PTPRSS	DEG_SCF_FBW7_1	0.5958
p.S364C	ACH-000338	Lymphoma	CCLE	PTPRSS	DEG_SCF_FBW7_1	0.643

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_SCF_FBW7_1	133:138	PTPRSS	FBXW7	0.7852	More...
Q96F05	Uncharacterized protein C11orf24	DEG_SCF_FBW7_1	360:365	PTPRSS	FBXW7	0.798	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons