DegronMD

Uniprot ID: Q8IX12

Source protein: Cell division cycle and apoptosis regulator protein 1

Source gene: CCAR1

Class: DEG_SCF_FBW7_1

Location: 119:125

E3 ligase: FBXW7

DEGRON score: 0.9487

ASA_SCORE: 79.2143

COIL: 0.8931

CONS_SCORE: 0.3481

DSS_SCORE: 0.4812

HELIX: 0.067

FCONS_SCORE: 0.9333

RIG_SCORE: 0.6278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q127H	TCGA-AX-A06F	UCEC	TCGA	LSTPQPT	DEG_SCF_FBW7_1	0.2778
p.V111F	TCGA-CZ-5453	KIRC	TCGA	LSTPQPT	DEG_SCF_FBW7_1	0.1111
p.P109Q	TCGA-EE-A17Z	SKCM	TCGA	LSTPQPT	DEG_SCF_FBW7_1	0.0556
p.S123I	DO229031	LICA	ICGC	LSTPQPT	DEG_SCF_FBW7_1	0.7341
p.K131N	DO229031	LICA	ICGC	LSTPQPT	DEG_SCF_FBW7_1	0.1667
p.R121S	DO229041	LICA	ICGC	LSTPQPT	DEG_SCF_FBW7_1	0.7427
p.P118T	DO232224	PBCA	ICGC	LSTPQPT	DEG_SCF_FBW7_1	0.3056
p.Q112H	DO41752	UCEC	ICGC	LSTPQPT	DEG_SCF_FBW7_1	0.1389
p.P118S	IGR-1	skin	COSMIC	LSTPQPT	DEG_SCF_FBW7_1	0.3056
p.P129H	HCT-15	large_intestine	COSMIC	LSTPQPT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IX12	Cell division cycle and apoptosis regulator protein 1	DEG_SCF_FBW7_1	119:125	LSTPQPT	FBXW7	0.9487	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons