DegronMD

Uniprot ID: Q8NFA0

Source protein: Ubiquitin carboxyl-terminal hydrolase 32

Source gene: USP32

Class: DEG_APCC_KENBOX_2

Location: 1423:1427

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9388

ASA_SCORE: 91.68

COIL: 0.6184

CONS_SCORE: 0.2303

DSS_SCORE: 0.6006

HELIX: 0.3424

FCONS_SCORE: 1.0017

RIG_SCORE: 0.6656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1425D	TCGA-85-A4JC	LUSC	TCGA	SKENL	DEG_APCC_KENBOX_2	0.6758
p.E1425D	DO45429	LUSC	ICGC	SKENL	DEG_APCC_KENBOX_2	0.6758
p.K1417E	TCGA-CG-4437	STAD	TCGA	SKENL	DEG_APCC_KENBOX_2	0.2778
p.K1417E	DO38467	STAD	ICGC	SKENL	DEG_APCC_KENBOX_2	0.2778
p.A1429V	SIDM01129	Small Cell Lung Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	0.2778
p.A1429V	ACH-000816	Lung Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	0.2778
p.A1429V	NCI-H524	lung	COSMIC	SKENL	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43526	Potassium voltage-gated channel subfamily KQT member 2	DEG_APCC_KENBOX_2	810:814	SKENL	APC,CDC20,FZR1	0.9043	More...
O43660	Pleiotropic regulator 1	DEG_APCC_KENBOX_2	61:65	SKENL	APC,CDC20,FZR1	0.982	More...
P30414	NK-tumor recognition protein	DEG_APCC_KENBOX_2	981:985	SKENL	APC,CDC20,FZR1	0.7579	More...
P42684	Tyrosine-protein kinase ABL2	DEG_APCC_KENBOX_2	97:101	SKENL	APC,CDC20,FZR1	0.9858	More...
Q03001	Dystonin	DEG_APCC_KENBOX_2	2695:2699	SKENL	APC,CDC20,FZR1	0.5258	More...
Q5VWT5	FYN-binding protein 2	DEG_APCC_KENBOX_2	563:567	SKENL	APC,CDC20,FZR1	0.8283	More...
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32	DEG_APCC_KENBOX_2	1423:1427	SKENL	APC,CDC20,FZR1	0.9388	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons