DegronMD - O43526(KCNQ2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P709H	TCGA-2H-A9GH	ESCA	TCGA	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.2222
p.A707T	TCGA-5P-A9JY	KIRP	TCGA	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.A707T	TCGA-CM-6163	COAD	TCGA	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.A707T	TCGA-X6-A8C6	SARC	TCGA	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.A707T	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.S808Y	TCGA-63-7021	LUSC	TCGA	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.2778
p.S808Y	TCGA-78-7155	LUAD	TCGA	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.2778
p.N813K	TCGA-66-2763	LUSC	TCGA	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation altering degron motif	0.6918
p.F805L	TCGA-AZ-6607	COAD	TCGA	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.1944
p.I807V	TCGA-BR-6452	STAD	TCGA	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.25
p.G716E	DO675	BLCA	ICGC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7199
p.S821P	DO222973	BTCA	ICGC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation blocking phosphorylation signal	0.5833
p.A817V	DO230315	COCA	ICGC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.25
p.A817V	DO232761	PBCA	ICGC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.25
p.P725L	DO234230	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1111
p.R707H	DO234234	ESAD	ICGC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.R707C	DO233662	GACA	ICGC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.I816T	DO16570	KIRC	ICGC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.2778
p.D717N	DO220899	MELA	ICGC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.6932
p.D717N	DO229453	SKCA	ICGC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.6932
p.G819E	DO222434	MELA	ICGC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.1944
p.G819R	DO222837	MELA	ICGC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.1944
p.R813M	DO37543	SKCM	ICGC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation altering degron motif	0.8632
p.V715M	DO43739	UCEC	ICGC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7208
p.A707V	SIDM02039	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.Y821C	SIDM01045	Endometrial Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation blocking phosphorylation signal	0.5833
p.Y821C	EN	endometrium	COSMIC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation blocking phosphorylation signal	0.5833
p.G727D	SIDM00537	Colorectal Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0556
p.P713L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7582
p.S803R	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.1389
p.S803R	ACH-000900	Lung Cancer	CCLE	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.1389
p.A706T	SIDM01617	Endometrial Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1389
p.S715C	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation altering degron motif	0.7541
p.F802V	SIDM00784	Glioma	GDSC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.1111
p.P704L	SIDM01750	Melanoma	GDSC	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.0833
p.S723L	ACH-000019	Breast Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.S723L	ACH-000028	Breast Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1667
p.V705M	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1111
p.V705M	ACH-000954	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1111
p.V705M	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPSTS	DEG_SPOP_SBC_1	713:717	Mutation rewiring degron network	0.1111
p.Y803C	EN	endometrium	COSMIC	SKENL	DEG_APCC_KENBOX_2	810:814	Mutation rewiring degron network	0.1389

Kaplan plot for KCNQ2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNQ2

UniProt ID: O43526

Entrez ID: 3785

Protein name: Potassium voltage-gated channel subfamily KQT member 2 (KQT-like 2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (Voltage-gated potassium channel subunit Kv7.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNQ2 in